Stk11 - serine/threonine kinase 11 Gene

Mus musculus

Also known as Lkb1; Par-4

Gene ID: 20869 | Gene type: protein coding

About Stk11

Summary

This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, Apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]

Stk11 Products(3)

mRNA	Protein	Name
NM_001301853.2	NP_001288782.1	serine/threonine-protein kinase STK11 isoform S
NM_001301854.2	NP_001288783.1	serine/threonine-protein kinase STK11 isoform 3
NM_011492.5	NP_035622.1	serine/threonine-protein kinase STK11 isoform L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables LRR domain binding	IPI IPI: Inferred from physical interaction	11741830	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17482548	MGI
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	17482548	MGI
enables protein kinase activator activity	IMP IMP: Inferred from mutant phenotype	16308421	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11853558	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16308421	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	25329316	MGI
acts upstream of or within Golgi localization	IMP IMP: Inferred from mutant phenotype	21111240	MGI
acts upstream of or within T cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	21487392	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21487392	MGI
acts upstream of axonogenesis	IGI IGI: Inferred from genetic interaction	21111240	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	17482548	MGI
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	25329316	MGI
acts upstream of or within dendrite extension	IMP IMP: Inferred from mutant phenotype	24367100	MGI
acts upstream of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	18381428	MGI
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	17482548	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16308421	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	11297520	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25329316	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27461402	MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	18381428	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	21111240	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	24768298	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18311138	MGI
involved in positive regulation of vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	24643070	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	21487392	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11853558	MGI
acts upstream of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	24768298	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	25329316	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24768298	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18381428	MGI
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	11853558	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	24367100	MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18381428	MGI
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	12234250	MGI
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	18774945	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	18381428	MGI
involved in vasculature development	IMP IMP: Inferred from mutant phenotype	11509733	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10400995	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11297520	MGI
located in membrane	IDA IDA: Inferred from direct assay	11297520	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10400995	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase STK11

liver kinase B1 homolog	serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1

Stk11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Stk11	Q9WTK7	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	19274086

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153358	TNG260	Inhibitor	99.91%	Unkown
HY-N6904	Crocetin monomethyl ester	Inhibitor	98.44%	Unkown
HY-RS13921	STK11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13922	STK11IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-153358A	(S)-TNG260		98.84%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stk11	NCBI	NCBI:6794

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