2. Gene
  3. Skp1 - S-phase kinase-associated protein 1 Gene

Skp1 - S-phase kinase-associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as OCP2; p19A; 15kDa; EMC19; Skp1a; OCP-II; Tceb1l; p19Skp1; 2610043E24Rik; 2610206H23Rik

Gene ID: 21402 | Gene type: protein coding

About Skp1

Summary

Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in centrosome and cytosol. Part of Cul7-RING ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; notochord; and sensory organ. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Skp1 Products(1)

mRNA Protein Name
NM_011543.4 NP_035673.3 S-phase kinase-associated protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11896578 MGI
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12140560 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29593216 MGI
acts upstream of or within protein monoubiquitination IGI
IGI: Inferred from genetic interaction
21343341 MGI
Cellular Component GO Annotation Evidence Reference Source
part of Cul7-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21572988 MGI
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
12140560 MGI
located in centrosome IDA
IDA: Inferred from direct assay
10485847 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12140560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-phase kinase-associated protein 1

S-phase kinase-associated protein 1A

cyclin-A/CDK2-associated protein p19

Skp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Skp1 Q9WTX5 Ppp1ca Mus musculus P62137
Antibody Array
17274640
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100237 SZL P1-41 99.92% Unkown
HY-10949 SMER3 Inhibitor 98.45% Unkown
HY-163019 EN884 Degrader / Unkown
HY-RS12973 SKP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Skp1 NCBI NCBI:6500