SKP1 - S-phase kinase associated protein 1 Gene

Homo sapiens

Also known as OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L

Gene ID: 6500 | Gene type: protein coding

About SKP1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,148,935-134,176,950 (from NCBI)

This gene has 13 transcripts (splice variants) and 244 orthologues. Ubiquitous expression in brain (RPKM 102.0), thyroid (RPKM 75.8) and 25 other tissues.

Summary

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

SKP1 Products(2)

mRNA	Protein	Name
NM_006930.4	NP_008861.2	S-phase kinase-associated protein 1 isoform a
NM_170679.3	NP_733779.1	S-phase kinase-associated protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables F-box domain binding	IPI IPI: Inferred from physical interaction	12820959	GOA
enables beta-catenin binding	IDA IDA: Inferred from direct assay	12820959	GOA
enables cullin family protein binding	IPI IPI: Inferred from physical interaction	18929646	GOA
enables molecular function activator activity	IDA IDA: Inferred from direct assay	29997255	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11099048	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15996101	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	15145941	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	12820959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15103331	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	16943429	GOA
involved in maintenance of protein location in nucleus	IPI IPI: Inferred from physical interaction	21378169	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	12820959	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15145941	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	15145941	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	12820959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15103331	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul7-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18498745	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	16943429	GOA
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	11956208	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18929646	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18929646	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKP1 Protein Structure

Skp1_POZ

Skp1

0
100
163 a.a.

Protein Preferred Names

Protein Names

S-phase kinase-associated protein 1

OCP-2

SKP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SKP1	P63208	TTC21A	Homo sapiens	A0A0B4J1Y2	Validated Y2H	25416956
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	TAP	27705803
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	Y2H Array	31515488
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	Validated Y2H	25416956
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	Y2H Array	25416956
Intra	SKP1	P63208	FBXO11	Homo sapiens	Q86XK2	Y2H Array	29892012
Intra	SKP1	P63208	SUGT1	Homo sapiens	Q9Y2Z0-2	Pull Down	18818696
Intra	SKP1	P63208	FBXO9	Homo sapiens	Q9UK97-2	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO7	Homo sapiens	Q9Y3I1	Anti Tag CoIP	26496610
Intra	SKP1	P63208	FBXO7	Homo sapiens	Q9Y3I1	MAPPIT	25416956
Intra	SKP1	P63208	FBXO7	Homo sapiens	Q9Y3I1	TAP	27705803
Intra	SKP1	P63208	FBXO7	Homo sapiens	Q9Y3I1	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO48	Homo sapiens	Q5FWF7	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO48	Homo sapiens	Q5FWF7	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO48	Homo sapiens	Q5FWF7	Y2H Array	32296183
Intra	SKP1	P63208	FBXO43	Homo sapiens	Q4G163	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO43	Homo sapiens	Q4G163	Y2H Array	32296183
Intra	SKP1	P63208	FBXO43	Homo sapiens	Q4G163	Validated Y2H	32296183
Intra	SKP1	P63208	CCNF	Homo sapiens	P41002	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3-2	Validated Y2H	32296183
Cross	SKP1	P63208	Fbxl3	Mus musculus	Q8C4V4	BiFC	23452855
Intra	SKP1	P63208	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SKP1	P63208	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SKP1	P63208	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	MTUS1	Homo sapiens	Q9ULD2-3	Validated Y2H	32296183
Intra	SKP1	P63208	MTUS1	Homo sapiens	Q9ULD2-3	Y2H Array	32296183
Intra	SKP1	P63208	MTUS1	Homo sapiens	Q9ULD2-3	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Y2H Array	25416956
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	TAP	27705803
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Y2H Array	32296183
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Anti Tag CoIP	26496610
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	MAPPIT	19159283
Intra	SKP1	P63208	FBXL8	Homo sapiens	Q96CD0	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3	Validated Y2H	25416956
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3	TAP	27705803
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3	Y2H Array	25416956
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO44	Homo sapiens	Q9H4M3	MAPPIT	19159283
Intra	SKP1	P63208	FBXL6	Homo sapiens	Q8N531	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXL6	Homo sapiens	Q8N531	MAPPIT	19159283
Intra	SKP1	P63208	FBXL6	Homo sapiens	Q8N531	TAP	27705803
Intra	SKP1	P63208	FBXW9	Homo sapiens	Q5XUX1	TAP	27705803
Intra	SKP1	P63208	FBXW9	Homo sapiens	Q5XUX1	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW9	Homo sapiens	Q5XUX1	MAPPIT	19159283
Intra	SKP1	P63208	FBXO46	Homo sapiens	Q6PJ61	TAP	27705803
Intra	SKP1	P63208	FBXO46	Homo sapiens	Q6PJ61	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW4	Homo sapiens	P57775	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW4	Homo sapiens	P57775	TAP	27705803
Intra	SKP1	P63208	FBXL22	Homo sapiens	Q6P050	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL22	Homo sapiens	Q6P050	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL22	Homo sapiens	Q6P050	Y2H Array	32296183
Intra	SKP1	P63208	FBXO3	Homo sapiens	Q9UK99	Y2H Array	31515488
Intra	SKP1	P63208	FBXO3	Homo sapiens	Q9UK99	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO3	Homo sapiens	Q9UK99	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO3	Homo sapiens	Q9UK99	TAP	27705803
Intra	SKP1	P63208	FBXO22	Homo sapiens	Q8NEZ5	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO22	Homo sapiens	Q8NEZ5	TAP	27705803
Intra	SKP1	P63208	FBXO22	Homo sapiens	Q8NEZ5	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	TAP	27705803
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Y2H Array	32296183
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	25416956
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	MAPPIT	32296183
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO17	Homo sapiens	Q96EF6	Y2H Array	25416956
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Y2H Array	25416956
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Y2H Array	32296183
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	FBXL5	Homo sapiens	Q9UKA1	Validated Y2H	25416956
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Validated Y2H	32296183
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Y2H Array	25416956
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Y2H Array	32296183
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Anti Tag CoIP	26496610
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Anti Tag CoIP	33961781
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Validated Y2H	25416956
Intra	SKP1	P63208	TTC9C	Homo sapiens	Q8N5M4	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO9	Homo sapiens	Q9UK97	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO9	Homo sapiens	Q9UK97	TAP	27705803
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	SLC	31467278
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	BRET	29997244
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	TAP	27705803
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	33961781
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	MAPPIT	25416956
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	Complementation	31467278
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	Lumier	29997244
Intra	SKP1	P63208	BTRC	Homo sapiens	Q9Y297	MAPPIT	31467278
Intra	SKP1	P63208	FBXO21	Homo sapiens	O94952	TAP	27705803
Intra	SKP1	P63208	FBXO21	Homo sapiens	O94952	Anti Tag CoIP	26085330
Intra	SKP1	P63208	FBXO21	Homo sapiens	O94952	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW11	Homo sapiens	Q9UKB1	CoIP	10644755
Intra	SKP1	P63208	FBXW11	Homo sapiens	Q9UKB1	TAP	27705803
Intra	SKP1	P63208	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW11	Homo sapiens	Q9UKB1	MAPPIT	19159283
Intra	SKP1	P63208	PPP1CA	Homo sapiens	P62136	Antibody Array	17274640
Intra	SKP1	P63208	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	17274640
Intra	SKP1	P63208	APIP	Homo sapiens	Q96GX9	Validated Y2H	25416956
Intra	SKP1	P63208	CUL1	Homo sapiens	Q13616	TAP	27705803
Intra	SKP1	P63208	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	SKP1	P63208	CUL1	Homo sapiens	Q13616	CoIP	12609982
Intra	SKP1	P63208	CUL1	Homo sapiens	Q13616	Pull Down	18818696
Intra	SKP1	P63208	CUL1	Homo sapiens	Q13616	ITC	18818696
Intra	SKP1	P63208	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	15070733
Intra	SKP1	P63208	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	23791182
Intra	SKP1	P63208	FBXO6	Homo sapiens	Q9NRD1	TAP	27705803
Intra	SKP1	P63208	FBXO6	Homo sapiens	Q9NRD1	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO6	Homo sapiens	Q9NRD1	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO6	Homo sapiens	Q9NRD1	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO6	Homo sapiens	Q9NRD1	Y2H Array	32296183
Intra	SKP1	P63208	KDM2B	Homo sapiens	Q8NHM5	Pull Down	16943429
Intra	SKP1	P63208	KDM2B	Homo sapiens	Q8NHM5	Anti Bait CoIP	33692209
Intra	SKP1	P63208	KDM2B	Homo sapiens	Q8NHM5	Anti Tag CoIP	33961781
Intra	SKP1	P63208	KDM2B	Homo sapiens	Q8NHM5	TAP	27705803
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	TAP	27705803
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Complementation	32296183
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Y2H Array	25416956
Intra	SKP1	P63208	FBXO2	Homo sapiens	Q9UK22	Y2H Array	32296183
Intra	SKP1	P63208	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	SKP1	P63208	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	BRET	29997244
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	Pull Down	12813041
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	Pull Down	18818696
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	Pull Down	23911321
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	TAP	27705803
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	Anti Tag CoIP	33961781
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309	Anti Bait CoIP	16376880
Intra	SKP1	P63208	FBXO31	Homo sapiens	Q5XUX0	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO25	Homo sapiens	Q8TCJ0-3	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL14	Homo sapiens	Q8N1E6	TAP	27705803
Intra	SKP1	P63208	FBXL14	Homo sapiens	Q8N1E6	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL14	Homo sapiens	Q8N1E6	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL14	Homo sapiens	Q8N1E6	Y2H Array	32296183
Intra	SKP1	P63208	FBXO27	Homo sapiens	Q8NI29	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO27	Homo sapiens	Q8NI29	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO27	Homo sapiens	Q8NI29	Y2H Array	32296183
Cross	SKP1	P63208	Fbxl21	Mus musculus	Q8BFZ4	BiFC	23452855
Intra	SKP1	P63208	FBXL12	Homo sapiens	Q9NXK8	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL12	Homo sapiens	Q9NXK8	Y2H Array	32296183
Intra	SKP1	P63208	FBXL12	Homo sapiens	Q9NXK8	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXL12	Homo sapiens	Q9NXK8	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL12	Homo sapiens	Q9NXK8	TAP	27705803
Intra	SKP1	P63208	FBXL2	Homo sapiens	Q9UKC9	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL2	Homo sapiens	Q9UKC9	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXL2	Homo sapiens	Q9UKC9	Y2H Array	32296183
Intra	SKP1	P63208	FBXL2	Homo sapiens	Q9UKC9	TAP	27705803
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Y2H Array	32296183
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	TAP	27705803
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Lumier	32814053
Intra	SKP1	P63208	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183
Intra	SKP1	P63208	FBXW5	Homo sapiens	Q969U6	TAP	27705803
Intra	SKP1	P63208	FBXW5	Homo sapiens	Q969U6	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW5	Homo sapiens	Q969U6	MAPPIT	19159283
Intra	SKP1	P63208	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Prey Pooling	25416956
Intra	SKP1	P63208	ANKRD36BP1	Homo sapiens	Q96IX9	Validated Y2H	25416956
Intra	SKP1	P63208	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Array	25416956
Intra	SKP1	P63208	KDM2A	Homo sapiens	Q9Y2K7	Anti Tag CoIP	15070733
Intra	SKP1	P63208	KDM2A	Homo sapiens	Q9Y2K7	TAP	27705803
Intra	SKP1	P63208	KDM2A	Homo sapiens	Q9Y2K7	Anti Tag CoIP	33961781
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309-2	MAPPIT	31467278
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309-2	SLC	31467278
Intra	SKP1	P63208	SKP2	Homo sapiens	Q13309-2	Complementation	31467278
Intra	SKP1	P63208	MYC	Homo sapiens	Q14901	Anti Bait CoIP	16376880
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	Y2H Array	32296183
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	TAP	27705803
Intra	SKP1	P63208	FBXO5	Homo sapiens	Q9UKT4	Y2H	17380122
Intra	SKP1	P63208	FBXO33	Homo sapiens	Q7Z6M2	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO33	Homo sapiens	Q7Z6M2	TAP	27705803
Intra	SKP1	P63208	FBXL20	Homo sapiens	Q96IG2	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXL20	Homo sapiens	Q96IG2	Y2H Array	32296183
Intra	SKP1	P63208	FBXL20	Homo sapiens	Q96IG2	TAP	27705803
Intra	SKP1	P63208	FBXL20	Homo sapiens	Q96IG2	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXL20	Homo sapiens	Q96IG2	Validated Y2H	32296183
Intra	SKP1	P63208	FBXL17	Homo sapiens	Q9UF56	TAP	27705803
Intra	SKP1	P63208	FBXL17	Homo sapiens	Q9UF56	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW2	Homo sapiens	Q9UKT8	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXW2	Homo sapiens	Q9UKT8	Y2H	11238952
Intra	SKP1	P63208	FBXW2	Homo sapiens	Q9UKT8	TAP	27705803
Intra	SKP1	P63208	FBXW8	Homo sapiens	Q8N3Y1	TAP	27705803
Intra	SKP1	P63208	FBXW8	Homo sapiens	Q8N3Y1	Anti Tag CoIP	15070733
Intra	SKP1	P63208	FBXW8	Homo sapiens	Q8N3Y1	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	Y2H Prey Pooling	32296183
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	Anti Tag CoIP	33961781
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	MAPPIT	32296183
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	Validated Y2H	32296183
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	Y2H Array	32296183
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	TAP	27705803
Intra	SKP1	P63208	FBXO4	Homo sapiens	Q9UKT5	Complementation	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SKP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76644	SKP1 Protein, Human (Biotinylated, His-Avi)	P63208 (P2-K163)	≥95%

SKP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82229	SKP1 Antibody (YA1974)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Mitochondrial Dna Depletion Syndrome 13

MTDPS13	Fbxl4 Deficiency
Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome	Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies	Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies
Fbxl4-Related Early-Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type
Bxl4-Related Early-Onset Mitochondrial Encephalopathy	Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13
Fbxl4-Related Early Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome, Type 13

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100237	SZL P1-41		99.92%	Unkown
HY-10949	SMER3	Inhibitor	98.45%	Unkown
HY-163019	EN884	Degrader	/	Unkown
HY-RS12973	SKP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SKP1	VGNC	VGNC:59042
Rattus norvegicus	SKP1	RGD	RGD:1359648
Mus musculus	SKP1	MGD	MGI:103575
Others	SKP1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.