2. Gene
  3. Timp2 - tissue inhibitor of metalloproteinase 2 Gene

Timp2 - tissue inhibitor of metalloproteinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Timp-2; D11Bwg1104e

Gene ID: 21858 | Gene type: protein coding

About Timp2

Summary

Enables Enzyme activator activity; Integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Timp2 Products(1)

mRNA Protein Name
NM_011594.3 NP_035724.2 metalloproteinase inhibitor 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
10827175 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
15901773 MGI
enables metalloendopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
10827176 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of neuron differentiation IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15901773 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
12950084 MGI
located in cell surface IDA
IDA: Inferred from direct assay
15901773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 2

tissue inhibitor of metalloproteinases 2

Recombinant Timp2 Proteins

Cat. No. Product Name Accession Purity
HY-P71137 TIMP-2 Protein, Mouse (HEK293, His) P25785 (C27-P220) ≥95%
HY-P71137A TIMP-2 Protein, Mouse (HEK293, C-His) P25785 (C27-P220) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14539 TIMP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp2 NCBI NCBI:7077