2. Gene
  3. Tlr1 - toll-like receptor 1 Gene

Tlr1 - toll-like receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 21897 | Gene type: protein coding

About Tlr1

Chromosome 5: 65,082,022-65,090,906 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 73 orthologues, 23 paralogues and is associated with 6 phenotypes. Biased expression in spleen adult (RPKM 12.1), colon adult (RPKM 6.6) and 11 other tissues.

Summary

Predicted to enable several functions, including Toll-like Receptor 2 binding activity; identical protein binding activity; and Lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tlr1 Products(2)

mRNA Protein Name
NM_030682.2 NP_109607.1 toll-like receptor 1 precursor
NM_001276445.1 NP_001263374.1 toll-like receptor 1 precursor

Tlr1 Protein Structure

PRK15370

PRK15370: cl33128 (37 - 132)

LRR

LRR: cl34836 (47 - 316)

LRR_1

LRR_1: sd00031 (49 - 72)

LRR_1

LRR_1: sd00031 (73 - 96)

LRR_1

LRR_1: sd00031 (97 - 117)

LRR_1

LRR_1: sd00031 (118 - 142)

LRR_1

LRR_1: sd00031 (143 - 155)

LRR_RI

LRR_RI: sd00033 (354 - 375)

PRK15370

PRK15370: cl33128 (376 - 486)

LRR_RI

LRR_RI: sd00033 (376 - 401)

LRR_RI

LRR_RI: sd00033 (402 - 426)

LRR_RI

LRR_RI: sd00033 (427 - 448)

LRR_RI

LRR_RI: sd00033 (449 - 471)

LRR_RI

LRR_RI: sd00033 (472 - 493)

LRR_RI

LRR_RI: sd00033 (494 - 517)

LRRCT

LRRCT: smart00082 (526 - 580)

TIR

TIR: smart00255 (638 - 781)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

toll-like receptor 1

TIL

toll/interleukin-1 receptor-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1180A Pam3CSK4 TFA Agonist 99.66% Unkown
HY-123942 Diprovocim Agonist 98.35% Unkown
HY-108471 CU-CPT22 Inhibitor ≥99.0% Unkown
HY-110353 CU-T12-9 Agonist 98.94% Unkown
HY-150501 Diprovocim-X Agonist 98.64% Unkown
HY-P1180 Pam3CSK4 Agonist / Unkown
HY-P1405 Pam3CSK4-Biotin Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr1 NCBI NCBI:7096