2. Gene
  3. Tnfrsf10b - tumor necrosis factor receptor superfamily, member 10b Gene

Tnfrsf10b - tumor necrosis factor receptor superfamily, member 10b Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B

Gene ID: 21933 | Gene type: protein coding

About Tnfrsf10b

Summary

Predicted to enable TRAIL receptor activity; identical protein binding activity; and protease binding activity. Predicted to be involved in TRAIL-activated apoptotic signaling pathway and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane. Is expressed in bladder; liver; renal vasculature; urethra of female; and urethra of male. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic Cancer (multiple); and urinary bladder Cancer. Orthologous to several human genes including TNFRSF10A (TNF Receptor Superfamily member 10a). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf10b Products(1)

mRNA Protein Name
NM_020275.4 NP_064671.2 tumor necrosis factor receptor superfamily member 10B precursor
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 10B

KILLER/DR5 TRAIL death-inducing receptor

death receptor 5

Recombinant Tnfrsf10b Proteins

Cat. No. Product Name Accession Purity
HY-P70821 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) Q9QZM4 (N53-S177) ≥95%
HY-P71378 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) Q9QZM4 (N53-S177) ≥95%
HY-P72977 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) Q9QZM4 (N53-S177) ≥95%
HY-P78363 TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) Q9QZM4 (N53-K180) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99260 Conatumumab Agonist 98.90% Phase 2
HY-P99261 Demcizumab Inhibitor ≥95.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14796 TNFRSF10B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990715 Ozekibart / Unkown
HY-P990901 Aplitabart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf10b NCBI NCBI:8795
Macaca fascicularis Tnfrsf10b NCBI NCBI:102133727