Tnfrsf11a - tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene

Mus musculus

Also known as OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

Gene ID: 21934 | Gene type: protein coding

About Tnfrsf11a

Chromosome 1: 105,708,443-105,775,709 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 493 orthologues, 21 paralogues and is associated with 51 phenotypes. Biased expression in colon adult (RPKM 2.9), duodenum adult (RPKM 8.1) and 1 other tissues.

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF Receptor Superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11a Products(1)

mRNA	Protein	Name
NM_009399.5	NP_033425.3	tumor necrosis factor receptor superfamily member 11A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10097072	MGI
enables tumor necrosis factor receptor activity	IMP IMP: Inferred from mutant phenotype	19940926	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian temperature homeostasis	IMP IMP: Inferred from mutant phenotype	19940926	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	10500098	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	11051546	MGI
acts upstream of or within multicellular organism development	IMP IMP: Inferred from mutant phenotype	10500098	MGI
acts upstream of or within multinuclear osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	11805147	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	10500098	MGI
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19940926	MGI
acts upstream of or within positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	11805147	MGI
involved in positive regulation of fever generation by positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	19940926	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23478294	MGI
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	19940926	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19940926	MGI
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	19940926	MGI
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19940926	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21844205	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	23478294	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnfrsf11a Protein Structure

TNFRSF11A

0
100
200
300
400
500
625 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 11A

osteoclast differentiation factor receptor	receptor activator of NF-KB
receptor activator of NF-kappaB

Tnfrsf11a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tnfrsf11a	O35305	Traf6	Mus musculus	P70196	Anti Bait CoIP	10097072
Intra	Tnfrsf11a	O35305	Traf3	Mus musculus	Q60803	Y2H	15102471
Intra	Tnfrsf11a	O35305	Bag6	Mus musculus	Q9Z1R2	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tnfrsf11a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72483	RANK/TNFRSF11A Protein, Mouse (HEK293, His)	O35305 (V31-S214)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14799	TNFRSF11A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14800	Tnfrsf11a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14801	Tnfrsf11a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfrsf11a	NCBI	NCBI:8792
Rattus norvegicus	Tnfrsf11a	NCBI	NCBI:498206

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