Traf3 - TNF receptor-associated factor 3 Gene

Mus musculus

Also known as amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN

Gene ID: 22031 | Gene type: protein coding

About Traf3

Summary

Enables protein kinase binding activity. Involved in several processes, including regulation of defense response to virus; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF Receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Traf3 Products(3)

mRNA	Protein	Name
NM_001286122.1	NP_001273051.1	TNF receptor-associated factor 3 isoform b
NM_001364364.1	NP_001351293.1	TNF receptor-associated factor 3 isoform b
NM_011632.3	NP_035762.2	TNF receptor-associated factor 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17158868	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17015635	MGI
involved in regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	16306937	MGI
involved in regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	16306937	MGI
involved in regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	16306937	MGI
involved in regulation of proteolysis	IDA IDA: Inferred from direct assay	17158868	MGI
involved in regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	17015635	MGI
involved in toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16306937	MGI
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17015635	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNF receptor-associated factor 3

CD40 receptor-associated factor 1	CD40-binding protein
RING-type E3 ubiquitin transferase TRAF3

Traf3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Traf3	Q60803	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	16306936
Cross	Traf3	Q60803	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	27094905
Intra	Traf3	Q60803	Ticam1	Mus musculus	Q80UF7	Anti Bait CoIP	16306937
Intra	Traf3	Q60803	Ticam1	Mus musculus	Q80UF7	Anti Bait CoIP	16306936
Intra	Traf3	Q60803	Mavs	Mus musculus	Q8VCF0	Pull Down	16858409
Intra	Traf3	Q60803	Rps27a	Mus musculus	P62991	Anti Bait CoIP	23334419
Intra	Traf3	Q60803	Rps27a	Mus musculus	P62991	Anti Bait CoIP	18083102
Intra	Traf3	Q60803	Traf2	Mus musculus	P39429	Anti Bait CoIP	20818435

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-NP135	Oxidized low density lipoprotein (Human)		/	Unkown
HY-RS14969	TRAF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14970	TRAF3IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14971	TRAF3IP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14972	TRAF3IP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf3	NCBI	NCBI:7187

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