2. Gene
  3. Cd27 - CD27 antigen Gene

Cd27 - CD27 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as S152; Tp55; Tnfrsf7

Gene ID: 21940 | Gene type: protein coding

About Cd27

Summary

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of apoptotic process and positive regulation of JNK cascade. Acts upstream of or within negative regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in several structures, including femur; hemolymphoid system; intestine; pituitary gland; and reproductive system. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2. Orthologous to human CD27 (CD27 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd27 Products(3)

mRNA Protein Name
NM_001033126.2 NP_001028298.1 CD27 antigen isoform a precursor
NM_001042564.1 NP_001036029.1 CD27 antigen isoform b precursor
NM_001286753.1 NP_001273682.1 CD27 antigen isoform c precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9692890 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
9366422 MGI
Biological Process GO Annotation Evidence Reference Source
involved in CD27 signaling pathway IDA
IDA: Inferred from direct assay
9366422 MGI
acts upstream of or within negative regulation of T cell apoptotic process IPI
IPI: Inferred from physical interaction
9692890 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
9692890 MGI
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
9692890 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
9833765 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
21508411 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
9366422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD27 antigen

CD antigen 27

CD27L receptor

T-cell activation antigen CD27

tumor necrosis factor receptor superfamily member 7

Recombinant Cd27 Proteins

Cat. No. Product Name Accession Purity
HY-P72743 CD27/TNFRSF7 Protein, Mouse (HEK293, His-Fc) P41272 (P24-R182) ≥95%
HY-P76216 CD27/TNFRSF7 Protein, Mouse (HEK293, His) P41272 (P24-R182) ≥95%
HY-P78256 CD27/TNFRSF7 Protein, Mouse (HEK293, mFc) P41272 (P24-R182) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99057 Varlilumab Inhibitor 96.09% Phase 2
HY-P990018 Boserolimab Inhibitor 99.00% Phase 2
HY-P99057A Varlilumab (anti-CD27) Inhibitor 99.68% Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113512 17-HDHA / Unkown
HY-120255 17(R)-HDHA / Unkown
HY-159886 MG-C-30 Agonist / Unkown
HY-RS02216 CD27 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990280 Anti-Mouse CD27 Antibody (RM27-3E5) Inhibitor / Unkown
HY-P990528 Anti-TNFRSF7/CD27 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd27 NCBI NCBI:939
Canis familiaris Cd27 NCBI NCBI:611674
Macaca fascicularis Cd27 NCBI NCBI:102139476
Leporidae Cd27 NCBI
Rattus norvegicus Cd27 NCBI NCBI:500318
Macaca mulatta Cd27 NCBI NCBI:712693