2. Gene
  3. Tnfrsf9 - tumor necrosis factor receptor superfamily, member 9 Gene

Tnfrsf9 - tumor necrosis factor receptor superfamily, member 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ILA; Ly63; 4-1BB; Cd137; CDw137; A930040I11Rik

Gene ID: 21942 | Gene type: protein coding

About Tnfrsf9

Summary

Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF Receptor Superfamily member 9). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf9 Products(3)

mRNA Protein Name
NM_001077508.1 NP_001070976.1 tumor necrosis factor receptor superfamily member 9 isoform 2 precursor
NM_001077509.1 NP_001070977.1 tumor necrosis factor receptor superfamily member 9 isoform 1 precursor
NM_011612.2 NP_035742.1 tumor necrosis factor receptor superfamily member 9 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9418902 MGI
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
8405064 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of immature T cell proliferation in thymus IDA
IDA: Inferred from direct assay
8405064 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 9

4-1BB ligand receptor

CD137 antigen

T-cell antigen 4-1BB

secreted CD137 antigen

Recombinant Tnfrsf9 Proteins

Cat. No. Product Name Accession Purity
HY-P7447 4-1BB/TNFRSF9 Protein, Mouse (HEK293, Fc, solution) P20334 (V24-L187) ≥95%
HY-P72884 4-1BB/TNFRSF9 Protein, Mouse (HEK293, His) P20334/NP_001070977 (V24-L187) ≥95%
HY-P74335 4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, Fc) NP_001070976 (V24-L211) ≥95%
HY-P77574 4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, His) NP_001070976 (V24-L211) ≥95%
HY-P7447A 4-1BB/TNFRSF9 Protein, Mouse (HEK293, C-hFc) P20334 (V24-L187) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990040 Exlinkibart Inhibitor 99.66% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14817 TNFRSF9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990757 Ragistomig / Unkown
HY-P99914 Emfizatamab / Unkown
HY-P990698 Umizortamig / Unkown
HY-P990738 Enristomig / Unkown
HY-P990742 Givastomig / Unkown
HY-P990778 Xirestomig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf9 NCBI NCBI:3604
Canis familiaris Tnfrsf9 NCBI NCBI:608274
Macaca fascicularis Tnfrsf9 NCBI NCBI:102127961
Macaca mulatta Tnfrsf9 NCBI NCBI:708281