Tnfsf11 - tumor necrosis factor (ligand) superfamily, member 11 Gene

Mus musculus

Also known as ODF; OPGL; RANKL; Ly109l; Trance

Gene ID: 21943 | Gene type: protein coding

About Tnfsf11

Chromosome 14: 78,514,885-78,545,483 reverse strand.GRCm39:CM001007.3

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 95 phenotypes. Biased expression in thymus adult (RPKM 1.), mammary gland adult (RPKM .5) and 8 other tissues.

Summary

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf11 Products(1)

mRNA	Protein	Name
NM_011613.4	NP_035743.2	tumor necrosis factor ligand superfamily member 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11859102	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11859102	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	19298785	MGI
enables tumor necrosis factor receptor superfamily binding	IPI IPI: Inferred from physical interaction	9367155	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19252502	MGI
acts upstream of JNK cascade	IGI IGI: Inferred from genetic interaction	22073305	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	9950424	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of or within bone resorption	IDA IDA: Inferred from direct assay	12490655	MGI
acts upstream of or within calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	21982707	MGI
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	24039232	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	11051546	MGI
acts upstream of or within mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11051546	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27336669	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	9950424	MGI
acts upstream of or within osteoclast development	IDA IDA: Inferred from direct assay	21841309	MGI
acts upstream of osteoclast differentiation	IDA IDA: Inferred from direct assay	15724149	MGI
acts upstream of or within osteoclast differentiation	IDA IDA: Inferred from direct assay	14662855	MGI
acts upstream of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within osteoclast differentiation	IGI IGI: Inferred from genetic interaction	15485831	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15750601	MGI
acts upstream of or within osteoclast proliferation	IDA IDA: Inferred from direct assay	22451653	MGI
acts upstream of or within paracrine signaling	IDA IDA: Inferred from direct assay	24190884	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	11051546	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19940926	MGI
acts upstream of or within positive regulation of JNK cascade	IGI IGI: Inferred from genetic interaction	22073305	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19298785	MGI
involved in positive regulation of corticotropin-releasing hormone secretion	IDA IDA: Inferred from direct assay	19940926	MGI
involved in positive regulation of fever generation by positive regulation of prostaglandin secretion	IDA IDA: Inferred from direct assay	19940926	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of or within positive regulation of osteoclast development	IDA IDA: Inferred from direct assay	18269914	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	15657444	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23478294	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	11051546	MGI
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	19252502	MGI
acts upstream of or within regulation of actin binding	IDA IDA: Inferred from direct assay	19715671	MGI
acts upstream of or within regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	12490655	MGI
acts upstream of or within tooth eruption	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	17442941	MGI
involved in tumor necrosis factor-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	19940926	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnfsf11 Protein Structure

TNF

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 11

OPG ligand	TNF-related activation-induced cytokine
osteoclast differentiation factor	osteoprotegerin ligand
receptor activator of NF-kappaB ligand	receptor activator of nuclear factor kappa-B ligand
tumor necrosis factor-related activation-induced cytokine

Recombinant Tnfsf11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7425	RANKL/TNFSF11 Protein, Mouse	O35235-1 (Q137-D316)	≥95%
HY-P73388	RANKL/TNFSF11 Protein, Mouse (HEK293, Fc)	AAC40113.1/ O35235-1(R72-D316)	≥95%
HY-P700226AF	Animal-Free RANK L/TNFSF11 Protein, Mouse (His)	O35235-1 (P143-D316)	≥95%
HY-P7425B	RANK L/TNFSF11 Protein, Mouse (HEK293, N-His)	O35235-1 (R72-D316)	≥95%
HY-P700259	RANKL/TNFSF11 Protein, Mouse (CHO, His)	O35235-1 (R72-D316)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9958A	Denosumab (anti-TNFSF11)	Inhibitor	95.00%	Phase 4

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14819	TNFSF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14820	Tnfsf11 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14821	TNFSF11 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfsf11	NCBI	NCBI:8600
Macaca fascicularis	Tnfsf11	NCBI	NCBI:102137946

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