UNC5B - unc-5 netrin receptor B Gene

Homo sapiens

Also known as UNC5H2; p53RDL1

Gene ID: 219699 | Gene type: protein coding

About UNC5B

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,212,570-71,302,864 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.8), gall bladder (RPKM 4.7) and 24 other tissues.

Summary

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in Cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

UNC5B Products(2)

mRNA	Protein	Name
NM_001244889.2	NP_001231818.1	netrin receptor UNC5B isoform 2 precursor
NM_170744.5	NP_734465.2	netrin receptor UNC5B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18469807	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	18469807	GOA
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18469807	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18469807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5B Protein Structure

I-set

TSP_1

ZU5

Death

0
200
400
600
800
945 a.a.

Protein Preferred Names

Protein Names

netrin receptor UNC5B

p53-regulated receptor for death and life protein 1

UNC5B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	UNC5B	Q8IZJ1	Agap2	Rattus norvegicus	Q8CGU4	Anti Tag CoIP	18469807

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UNC5B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74481	UNC5B Protein, Human (HEK293, His)	Q8IZJ1 (G27-P363)	≥95%
HY-P74482	UNC5B Protein, Human (HEK293, hFc)	Q8IZJ1-1 (G27-P363)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15472	UNC5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UNC5B	VGNC	VGNC:78722
Bos taurus	UNC5B	VGNC	VGNC:36671
Felis catus	UNC5B	VGNC	VGNC:66829
Rattus norvegicus	UNC5B	RGD	RGD:621756
Mus musculus	UNC5B	MGD	MGI:894703
Canis familiaris	UNC5B	VGNC	VGNC:48140
Others	UNC5B	NCBI

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