LTO1 - LTO1 maturation factor of ABCE1 Gene

Homo sapiens

Also known as CIAB1; TAOS1; ORAOV1

Gene ID: 220064 | Gene type: protein coding

About LTO1

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:69,665,563-69,675,353 (from NCBI)

This gene has 18 transcripts (splice variants) and 111 orthologues. Ubiquitous expression in testis (RPKM 2.2), skin (RPKM 2.1) and 25 other tissues.

Summary

Involved in protein maturation by [4Fe-4S] cluster transfer; ribosomal large subunit biogenesis; and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

LTO1 Products(1)

mRNA	Protein	Name
NM_153451.3	NP_703152.1	protein LTO1 homolog

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24930674	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein maturation by [4Fe-4S] cluster transfer	IDA IDA: Inferred from direct assay	26182403	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	23318452	GOA
involved in translational initiation	IMP IMP: Inferred from mutant phenotype	23318452	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTO1 Protein Structure

Yae1_N

0
100
137 a.a.

Protein Preferred Names

Protein Names

protein LTO1 homolog

LTO1, ABCE1 maturation factor

LTO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LTO1	Q8WV07	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	LTO1	Q8WV07	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	LTO1	Q8WV07	YAE1	Homo sapiens	Q9NRH1	Y2H Prey Pooling	32296183
Intra	LTO1	Q8WV07	YAE1	Homo sapiens	Q9NRH1	Validated Y2H	32296183
Intra	LTO1	Q8WV07	YAE1	Homo sapiens	Q9NRH1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cone-Rod Dystrophy 3

CORD3

Dystrophy, Cone Rod, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07886	LTO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LTO1	VGNC	VGNC:103111
Macaca mulatta	LTO1	VGNC	VGNC:74308
Bos taurus	LTO1	VGNC	VGNC:54908
Canis familiaris	LTO1	VGNC	VGNC:56091
Mus musculus	LTO1	MGD	MGI:1919534
Rattus norvegicus	LTO1	RGD	RGD:1304637

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