2. Gene
  3. FCAR - Fc alpha receptor Gene

FCAR - Fc alpha receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD89; FcalphaR; FcalphaRI; CTB-61M7.2

Gene ID: 2204 | Gene type: protein coding

About FCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,874,235-54,891,420 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 69 orthologues and 25 paralogues. Restricted expression toward bone marrow (RPKM 95.4).

Summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a Transmembrane Glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

FCAR Products(8)

mRNA Protein Name
NM_002000.4 NP_001991.1 immunoglobulin alpha Fc receptor isoform a precursor
NM_133269.4 NP_579803.1 immunoglobulin alpha Fc receptor isoform b precursor
NM_133271.4 NP_579805.1 immunoglobulin alpha Fc receptor isoform c precursor
NM_133272.4 NP_579806.1 immunoglobulin alpha Fc receptor isoform d
NM_133273.4 NP_579807.1 immunoglobulin alpha Fc receptor isoform e
NM_133274.4 NP_579808.1 immunoglobulin alpha Fc receptor isoform f
NM_133277.4 NP_579811.1 immunoglobulin alpha Fc receptor isoform g
NM_133278.4 NP_579812.1 immunoglobulin alpha Fc receptor isoform h

FCAR Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (29 - 117)

Ig_2

Ig_2: Immunoglobulin domain (126 - 215)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

immunoglobulin alpha Fc receptor

Fc fragment of IgA receptor

Recombinant FCAR Proteins

Cat. No. Product Name Accession Purity
HY-P72657 FCAR/CD89 Protein, Human (HEK293, His) P24071-1 (Q22-N227) ≥95%

Related Diseases

Diseases Alias
Iga Glomerulonephritis

Iga Nephropathy

Glomerulonephritis, Iga

Berger'S Iga Or Igg Nephropathy

Focal Glomerulonephritis

Primary Iga Nephropathy

Segmental Glomerulonephritis

Berger Disease

Berger'S Disease

Igan

Nephritis, Iga Type

Nephropathy Iga

Glomerulonephritis Focal

Iga Nephropathy, Susceptibility To

Primary Immunoglobulin A Nephropathy
Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis

Portal Cirrhosis

Alcoholic Cirrhosis Of Liver

Liver Cirrhosis, Alcoholic

Laennec'S Cirrhosis

Laennec'S Cirrhosis, Alcoholic

Alcohol Cirrhosis

Alcoholic Laennec Cirrhosis

Alcoholic Cirrhosis Nos

Etoh Cirrhosis

Alcohol Hepatic Cirrhosis

Alcohol Liver Cirrhosis

Laennec Cirrhosis
Glomerulonephritis

Bright'S Disease
Erythema Elevatum Diutinum
Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis

Hypersensitivity Angiitis

Cutaneous Leukocytoclastic Vasculitis

Leukocytoclastic Angiitis

Vasculitis, Leukocytoclastic, Cutaneous

Leukocytoclastic Vasculitis

Cutaneous Leukocytoclastic Angiitis

Cutaneous Hypersensitivity Vasculitis

Vasculitis Hypersensitivity

Drug Induced Cutaneous Vasculitis

Allergic Vasculitis
Inflammatory Bowel Disease 10

Inflammatory Bowel Disease 10

IBD10

Inflammatory Bowel Disease 10, Susceptibility To

Bowel Disease, Inflammatory, Type 10
Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases

Immune Complex Disease

Type Iii Hypersensitivity Reaction Disease
Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura

Iga Vasculitis

Allergic Purpura

Anaphylactoid Purpura

Rheumatoid Purpura

Immunoglobulin A Vasculitis

Vascular Purpura

Purpura Rheumatica

Henoch-Schönlein Purpura

Autoimmune Purpura

Henoch-Schnlein Purpura

Henoch-Sch@Nlein Purpura

Henoch-Scholein Purpura

Purpura, Autoimmune

Henoch Schonlein Purpura

Immunoglobulin-A Vasculitis

Purpura, Schonlein-Henoch

Purpura, Schönlein-Henoch

Hsp -

Schönlein-Henoch Purpura
Immunoglobulin Alpha Deficiency

Iga Deficiency

Gamma-A-Globulin Deficiency

Immunoglobulin A Deficiency
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04821 FCAR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FCAR VGNC VGNC:72627
Rattus norvegicus FCAR RGD RGD:1303082
Bos taurus FCAR VGNC VGNC:28929
Others FCAR NCBI