ARL5B - ADP ribosylation factor like GTPase 5B Gene

Homo sapiens

Also known as ARL8

Gene ID: 221079 | Gene type: protein coding

About ARL5B

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:18,659,431-18,681,639 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 30 paralogues. Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues.

Summary

ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the Ras superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

ARL5B Products(1)

mRNA	Protein	Name
NM_178815.5	NP_848930.1	ADP-ribosylation factor-like protein 5B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to Golgi membrane	IMP IMP: Inferred from mutant phenotype	25795912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL5B Protein Structure

Arf

0
100
179 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 5B

ADP-ribosylation factor-like 5B

Related Diseases

Diseases

Alias

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00992	ARL5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARL5B	VGNC	VGNC:38116
Felis catus	ARL5B	VGNC	VGNC:59925
Bos taurus	ARL5B	VGNC	VGNC:26148
Macaca mulatta	ARL5B	VGNC	VGNC:69886
Mus musculus	ARL5B	MGD	MGI:1923119
Rattus norvegicus	ARL5B	RGD	RGD:1305569

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