MICU2 - mitochondrial calcium uptake 2 Gene

Homo sapiens

Also known as EFHA1; 1110008L20Rik

Gene ID: 221154 | Gene type: protein coding

About MICU2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,492,691-21,604,170 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 25.3), adrenal (RPKM 19.4) and 25 other tissues.

Summary

Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]

MICU2 Products(1)

mRNA	Protein	Name
NM_152726.3	NP_689939.1	calcium uptake protein 2, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	31397067	GOA
enables calcium ion sensor activity	IDA IDA: Inferred from direct assay	28615291	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24560927	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	24560927	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium import into the mitochondrion	IDA IDA: Inferred from direct assay	28615291	GOA
involved in calcium import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	26903221	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	32494073	GOA
involved in mitochondrial calcium ion homeostasis	IDA IDA: Inferred from direct assay	32494073	GOA
involved in mitochondrial calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	26903221	GOA
involved in mitochondrial calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	24560927	GOA
involved in negative regulation of mitochondrial calcium ion concentration	IDA IDA: Inferred from direct assay	24560927	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28615291	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	27099988	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	24231807	GOA
part of uniplex complex	IDA IDA: Inferred from direct assay	24231807	GOA
part of uniplex complex	IPI IPI: Inferred from physical interaction	32494073	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICU2 Protein Structure

EF-hand_8

0
100
200
300
400
434 a.a.

Protein Preferred Names

Protein Names

calcium uptake protein 2, mitochondrial

EF hand domain family A1

MICU2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MICU2	Q8IYU8	MICU1	Homo sapiens	Q9BPX6	Anti Bait CoIP	26387864
Intra	MICU2	Q8IYU8	MICU1	Homo sapiens	Q9BPX6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myopathy With Extrapyramidal Signs

Proximal Myopathy With Extrapyramidal Signs	MPXPS
Myopathy, With Extrapyramidal Signs

Sagittal Sinus Thrombosis

Thrombosis Of Superior Longitudinal Sinus	Thrombosis Of Superior Sagittal Sinus
Thrombosis Superior Sagittal Sinus

Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary	Malignant Ovarian Endometrioid Tumor
Ovarian Endometrioid Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08432	MICU2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MICU2	MGD	MGI:1915764
Macaca mulatta	MICU2	VGNC	VGNC:74629
Rattus norvegicus	MICU2	RGD	RGD:619739
Felis catus	MICU2	VGNC	VGNC:63495
Canis familiaris	MICU2	VGNC	VGNC:43221
Bos taurus	MICU2	VGNC	VGNC:31462

Name
Email *

	Sorry, but the email address you supplied was invalid.