2. Gene
  3. ADGRG5 - adhesion G protein-coupled receptor G5 Gene

ADGRG5 - adhesion G protein-coupled receptor G5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PGR27; GPR114

Gene ID: 221188 | Gene type: protein coding

About ADGRG5

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,529,073-57,577,189 (from NCBI)

This gene has 7 transcripts (splice variants), 113 orthologues and 42 paralogues. Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues.

Summary

This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ADGRG5 Products(3)

mRNA Protein Name
NM_001304376.3 NP_001291305.1 adhesion G-protein coupled receptor G5 isoform 1 precursor
NM_001318481.2 NP_001305410.1 adhesion G-protein coupled receptor G5 isoform 2 precursor
NM_153837.4 NP_722579.1 adhesion G-protein coupled receptor G5 isoform 1 precursor

ADGRG5 Protein Structure

GPS

GPS: GPCR proteolysis site, GPS, motif (186 - 233)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (248 - 498)

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  • 528 a.a.
Protein Preferred Names Protein Names

adhesion G-protein coupled receptor G5

G protein-coupled receptor 114

Recombinant ADGRG5 Proteins

Cat. No. Product Name Accession Purity
HY-P76960 GPR114 Protein, Human (HEK293, Fc) Q8IZF4 (E22-G184) ≥95%

Related Diseases

Diseases Alias
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Alveoli Adenoma

Alveolar Adenoma

Adenoma Of Alveoli

Adenoma Of The Alveoli
Bronchial Benign Neoplasm

Bronchus Neoplasm

Neoplasm Of Bronchus

Bronchial Neoplasms

Bronchial Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101483 Dihydromunduletone Antagonist 99.96% Unkown
HY-RS00358 ADGRG5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADGRG5 VGNC VGNC:25668
Rattus norvegicus ADGRG5 RGD RGD:1305559
Macaca mulatta ADGRG5 VGNC VGNC:69634
Felis catus ADGRG5 VGNC VGNC:59636
Mus musculus ADGRG5 MGD MGI:2685955
Canis familiaris ADGRG5 VGNC VGNC:37647
Others ADGRG5 NCBI