PI16 - peptidase inhibitor 16 Gene

Homo sapiens

Also known as CD364; PSPBP; CRISP9; MSMBBP

Gene ID: 221476 | Gene type: protein coding

About PI16

This gene has 4 transcripts (splice variants) and 85 orthologues. Biased expression in urinary bladder (RPKM 35.7), heart (RPKM 28.3) and 12 other tissues.

Summary

Predicted to enable peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

PI16 Products(2)

mRNA	Protein	Name
NM_001199159.2	NP_001186088.1	peptidase inhibitor 16 precursor
NM_153370.3	NP_699201.2	peptidase inhibitor 16 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PI16 Protein Structure

CAP

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

peptidase inhibitor 16

PSP94-binding protein

PI16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PI16	Q6UXB8	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	PI16	Q6UXB8	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy	Mecd
Corneal Dystrophy, Meesmann Epithelial	Juvenile Hereditary Epithelial Dystrophy
Corneal Dystrophy, Juvenile Epithelial Of Meesmann	MECD1
Meesmann Corneal Dystrophy 1	Meesmann Corneal Epithelial Dystrophy
Meesmann Epithelial Corneal Dystrophy	Corneal Dystrophy, Juvenile Epithelial, Of Meesmann
Stocker-Holt Dystrophy	Meesman Dystrophy
Meesman'S Corneal Dystrophy	Juvenile Hereditary Epithelial Dystrophy Of Meesmann
Corneal Dystrophy, Meesmann 1	Juvenile Epithelial Corneal Dystrophy Of Meesmann
Mcd	Dystrophy, Corneal, Meesmann

Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

Methylcobalamin Deficiency, Cblg Type	HMAG
Methionine Synthase Deficiency	Methylcobalamin Deficiency Type Cblg
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type	Homocystinuria-Megaloblastic Anemia Cblg Type
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type	Methylcobalamin Deficiency Cbl G Type
Homocystinuria Due To Defect In Methylation Cbl G	Cblg
Functional Methionine Synthase Deficiency Type Cblg	Methylcobalamin Deficiency Cblg Type
Arakawa Syndrome 2

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Epithelial And Subepithelial Dystrophy

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10462	PI16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165648S	PtdIns-(1-palmitoyl-d9, 2-palmitoyl) sodium salt		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PI16	RGD	RGD:1304760
Mus musculus	PI16	MGD	MGI:1921366
Felis catus	PI16	VGNC	VGNC:97555
Macaca mulatta	PI16	VGNC	VGNC:81497
Canis familiaris	PI16	VGNC	VGNC:44515
Bos taurus	PI16	VGNC	VGNC:32853
Others	PI16	NCBI

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