TMEM86A - transmembrane protein 86A Gene

Homo sapiens

Gene ID: 144110 | Gene type: protein coding

About TMEM86A

This gene has 5 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 12.8), skin (RPKM 8.6) and 23 other tissues.

Summary

Predicted to enable alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM86A Products(1)

mRNA	Protein	Name
NM_153347.3	NP_699178.1	lysoplasmalogenase-like protein TMEM86A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables alkenylglycerophosphocholine hydrolase activity	IDA IDA: Inferred from direct assay	36592658	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM86A Protein Structure

YhhN

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

lysoplasmalogenase-like protein TMEM86A

TMEM86A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM86A	Q8N2M4	NCAPH2	Homo sapiens	Q6IBW4-4	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	NCAPH2	Homo sapiens	Q6IBW4-4	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	HAVCR2	Homo sapiens	Q8TDQ0	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	HAVCR2	Homo sapiens	Q8TDQ0	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	HAVCR2	Homo sapiens	Q8TDQ0	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	GJC1	Homo sapiens	P36383	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GJC1	Homo sapiens	P36383	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	PI16	Homo sapiens	Q6UXB8	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	PI16	Homo sapiens	Q6UXB8	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GJB4	Homo sapiens	Q9NTQ9	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	GJB4	Homo sapiens	Q9NTQ9	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	GJB4	Homo sapiens	Q9NTQ9	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	MS4A2	Homo sapiens	Q01362	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	MS4A2	Homo sapiens	Q01362	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	TYROBP	Homo sapiens	O43914	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	TYROBP	Homo sapiens	O43914	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	RNF185	Homo sapiens	Q96GF1	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	RNF185	Homo sapiens	Q96GF1	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	AQP3	Homo sapiens	Q92482	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	AQP3	Homo sapiens	Q92482	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	KCNA1	Homo sapiens	Q09470	Y2H Array	32296183
Intra	TMEM86A	Q8N2M4	KCNA1	Homo sapiens	Q09470	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	TMEM86A	Q8N2M4	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183
Intra	TMEM86A	Q8N2M4	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14743	TMEM86A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM86A	RGD	RGD:1305749
Felis catus	TMEM86A	VGNC	VGNC:66366
Bos taurus	TMEM86A	VGNC	VGNC:36116
Macaca mulatta	TMEM86A	VGNC	VGNC:101415
Canis familiaris	TMEM86A	VGNC	VGNC:47608
Mus musculus	TMEM86A	MGD	MGI:1915143

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