2. Gene
  3. DAGLB - diacylglycerol lipase beta Gene

DAGLB - diacylglycerol lipase beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KCCR13L; DAGLBETA

Gene ID: 221955 | Gene type: protein coding

About DAGLB

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:6,409,129-6,447,954 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 8.1), brain (RPKM 8.1) and 25 other tissues.

Summary

Enables Lipase activity. Involved in arachidonic acid metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

DAGLB Products(2)

mRNA Protein Name
NM_001142936.2 NP_001136408.1 diacylglycerol lipase-beta isoform 2
NM_139179.4 NP_631918.3 diacylglycerol lipase-beta isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipase activity IDA
IDA: Inferred from direct assay
14610053 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
14610053 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14610053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAGLB Protein Structure

Lipase_3

Lipase_3: Lipase (class 3) (370 - 502)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
Protein Preferred Names Protein Names

diacylglycerol lipase-beta

DAGL-beta

DAGLB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DAGLB Q8NCG7 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
DAGLB Q8NCG7 CLP1 Homo sapiens Q92989
Y2H Prey Pooling
32296183
Intra
DAGLB Q8NCG7 CLP1 Homo sapiens Q92989
Y2H Array
32296183
Intra
DAGLB Q8NCG7 CLP1 Homo sapiens Q92989
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03521 DAGLB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DAGLB VGNC VGNC:71803
Bos taurus DAGLB VGNC VGNC:27873
Mus musculus DAGLB MGD MGI:2442032
Felis catus DAGLB VGNC VGNC:61333
Rattus norvegicus DAGLB RGD RGD:1310193
Canis familiaris DAGLB VGNC VGNC:39765