FGB - fibrinogen beta chain Gene

Homo sapiens

Also known as HEL-S-78p

Gene ID: 2244 | Gene type: protein coding

About FGB

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,562,980-154,572,807 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues, 25 paralogues and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 2456.5).

Summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by Thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]

FGB Products(9)

mRNA	Protein	Name
NM_001184741.1	NP_001171670.1	fibrinogen beta chain isoform 2 preproprotein
NM_001382759.1	NP_001369688.1	fibrinogen beta chain isoform 3 preproprotein
NM_001382760.1	NP_001369689.1	fibrinogen beta chain isoform 4 preproprotein
NM_001382761.1	NP_001369690.1	fibrinogen beta chain isoform 5 preproprotein
NM_001382762.1	NP_001369691.1	fibrinogen beta chain isoform 6 preproprotein
NM_001382763.1	NP_001369692.1	fibrinogen beta chain isoform 7 preproprotein
NM_001382764.1	NP_001369693.1	fibrinogen beta chain isoform 8 preproprotein
NM_001382765.1	NP_001369694.1	fibrinogen beta chain isoform 9 preproprotein
NM_005141.5	NP_005132.2	fibrinogen beta chain isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to cell adhesion molecule binding	IDA IDA: Inferred from direct assay	9182580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12706644	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	19996109	GOA
contributes to signaling receptor binding	IDA IDA: Inferred from direct assay	10903502	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	8910396	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	10903502	GOA
involved in fibrinolysis	IDA IDA: Inferred from direct assay	16846481	GOA
involved in induction of bacterial agglutination	IDA IDA: Inferred from direct assay	24367264	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	10903502	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10903502	GOA
involved in plasminogen activation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in platelet aggregation	IDA IDA: Inferred from direct assay	6281794	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10903502	GOA
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	8100742	GOA
involved in positive regulation of peptide hormone secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	15739255	GOA
involved in protein polymerization	IDA IDA: Inferred from direct assay	12706644	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	8910396	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	6777381	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	6777381	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	6777381	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	6777381	GOA
part of fibrinogen complex	IDA IDA: Inferred from direct assay	6688356	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	6777381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGB Protein Structure

Fib_alpha

Fibrinogen_C

0
100
200
300
400
491 a.a.

Protein Preferred Names

Protein Names

fibrinogen beta chain

beta-fibrinogen

FGB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	FGB	P02675	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	BiFC	20162731

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Afibrinogenemia, Congenital

Congenital Afibrinogenemia	Afibrinogenemia
Factor I Deficiency	Familial Afibrinogenemia
Hypofibrinogenemia, Congenital	Fibrinogen Deficiency
Afibrinogenemia Congenital	CAFBN
Congenital Hypofibrinogenemia	Hypofibrinogenemia
Complement Factor I Deficiency

Hypofibrinogenemia, Familial

Familial Hypofibrinogenemia

Thrombosis

Thrombosis Of Blood Vessel

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Thrombophilia

Hypercoagulability State

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Lateral Medullary Syndrome

Posterior Inferior Cerebellar Artery Syndrome	Wallenberg Syndrome
Vertebral Artery Syndrome	Wallenberg'S Syndrome
Pica Syndrome

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Alopecia-Mental Retardation Syndrome 1

APMR1	Alopecia-Intellectual Disability Syndrome 1
Amr Syndrome	Alopecia-Intellectual Disability Syndrome
Amr Syndrome 1	Alopecia With Severe Intellectual Deficit
Apmr	Alopecia Intellectual Disbility Syndrome 1
Perniola-Krajewska-Carnevale Syndrome	Alopecia - Intellectual Disability Syndrome
Alopecia With Mental Retardation Syndrome 1	Perniola Krajewska Carnevale Syndrome

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04879	FGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGB	MGD	MGI:99501
Canis familiaris	FGB	VGNC	VGNC:54207
Rattus norvegicus	FGB	RGD	RGD:2604
Felis catus	FGB	VGNC	VGNC:62238
Macaca mulatta	FGB	VGNC	VGNC:72641
Bos taurus	FGB	VGNC	VGNC:28963

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