Hrh4 - histamine receptor H4 Gene

Mus musculus

Also known as H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105

Gene ID: 225192 | Gene type: protein coding

About Hrh4

Chromosome 18: 13,140,047-13,155,939 forward strand.GRCm39:CM001011.3

This gene has 3 transcripts (splice variants), 105 orthologues, 32 paralogues and is associated with 13 phenotypes. Biased expression in testis adult (RPKM 1.) and spleen adult (RPKM .1).

Summary

Enables Histamine Receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and inflammatory response. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Orthologous to human HRH4 (Histamine Receptor H4). [provided by Alliance of Genome Resources, Apr 2022]

Hrh4 Products(1)

mRNA	Protein	Name
NM_153087.2	NP_694727.1	histamine H4 receptor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histamine receptor activity	IDA IDA: Inferred from direct assay	11561071	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11561071	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh4 Protein Structure

7tm_GPCRs

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

histamine H4 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06368	HRH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06369	Hrh4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06370	Hrh4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hrh4	NCBI	NCBI:59340

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