FGF11 - fibroblast growth factor 11 Gene

Homo sapiens

Also known as FHF3; FHF-3; FGF-11

Gene ID: 2256 | Gene type: protein coding

About FGF11

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,438,298-7,444,937 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 277 orthologues and 21 paralogues. Broad expression in adrenal (RPKM 9.9), skin (RPKM 7.0) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FGF11 Products(2)

mRNA	Protein	Name
NM_001303460.2	NP_001290389.1	fibroblast growth factor 11 isoform 2
NM_004112.4	NP_004103.1	fibroblast growth factor 11 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF11 Protein Structure

FGF

0
100
200
225 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor 11

fibroblast growth factor homologous factor 3

Recombinant FGF11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700054AF	Animal-Free FGF-11 isoform 1 Protein, Human (His)	Q92914 (M1-P225)	≥95%
HY-P700055AF	Animal-Free FGF-11 isoform 2 Protein, Human (His)	NP_001290389.1 (M1-P166)	≥95%

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 27

Spinocerebellar Ataxia Type 27	SCA27
Cerebellar Ataxia Autosomal Dominant Fgf14-Related	Vestibulocerebellar Disorder With Predominant Ocular Signs
Cerebellar Ataxia, Autosomal Dominant, Fgf14-Related	Nystagmus 4, Congenital, Autosomal Dominant, Formerly
Nys4, Formerly	Ataxia, Spinocerebellar, Type 27

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04888	FGF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FGF11	VGNC	VGNC:104600
Bos taurus	FGF11	VGNC	VGNC:28971
Canis familiaris	FGF11	VGNC	VGNC:40840
Rattus norvegicus	FGF11	RGD	RGD:620162
Mus musculus	FGF11	MGD	MGI:109167
Felis catus	FGF11	VGNC	VGNC:62245

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