FGL1 - fibrinogen like 1 Gene

Homo sapiens

Also known as HPS; HFREP1; HP-041; LFIRE1; LFIRE-1

Gene ID: 2267 | Gene type: protein coding

About FGL1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,864,389-17,895,538 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 25 paralogues. Restricted expression toward liver (RPKM 275.4).

Summary

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

FGL1 Products(4)

mRNA	Protein	Name
NM_004467.4	NP_004458.3	fibrinogen-like protein 1 precursor
NM_147203.2	NP_671736.2	fibrinogen-like protein 1 precursor
NM_201552.1	NP_963846.1	fibrinogen-like protein 1 precursor
NM_201553.1	NP_963847.1	fibrinogen-like protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30580966	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hepatocyte proliferation	IDA IDA: Inferred from direct assay	19880967	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	30580966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGL1 Protein Structure

Fibrinogen_C

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

fibrinogen-like protein 1

hepassocin

Recombinant FGL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70737	FGL1 Protein, Human (HEK293, His, solution)	Q08830 (L23-I312)	≥95%
HY-P70740	FGL1 Protein, Human (HEK293, mFc)	Q08830 (L23-I312)	≥95%
HY-P72369	FGL1 Protein, Human (Biotinylated, HEK293, Avi-His)	Q08830 (L23-I312)	≥95%
HY-P78128	FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi)	Q08830 (D64-N305)	≥95%
HY-P78443	FGL1 protein, Human (HEK293, 242a.a, His-Avi)	Q08830 (D64-N305)	≥95%
HY-P70740A	FGL1 Protein, Human (HEK293, mFc, solution)	Q08830 (L23-I312)	≥95%
HY-P701077	FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, hFc)	Q08830 (D64-N305)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99156	Relatlimab		97.56%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04927	FGL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164308	SA-15-P	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FGL1	VGNC	VGNC:78497
Rattus norvegicus	FGL1	RGD	RGD:620169
Mus musculus	FGL1	MGD	MGI:102795
Bos taurus	FGL1	VGNC	VGNC:28992
Macaca mulatta	FGL1	VGNC	VGNC:84000
Canis familiaris	FGL1	VGNC	VGNC:40864
Macaca fascicularis	FGL1	NCBI	NCBI:102118020
Others	FGL1	NCBI

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