P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

Mus musculus

Also known as P2X3; 4930513E20Rik

Gene ID: 228139 | Gene type: protein coding

About P2rx3

Chromosome 2: 84,828,927-84,867,806 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in testis adult (RPKM 11.8), CNS E14 (RPKM 1.5) and 2 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 Products(1)

mRNA	Protein	Name
NM_145526.2	NP_663501.2	P2X purinoceptor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables extracellularly ATP-gated monoatomic cation channel activity	IGI IGI: Inferred from genetic interaction	15081800	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within behavioral response to pain	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within behavioral response to pain	IMP IMP: Inferred from mutant phenotype	11069181	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17074061	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	11069181	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17074061	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17074061	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	11069182	MGI
acts upstream of or within monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	11069181	MGI
acts upstream of or within neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	12813150	MGI
acts upstream of or within peristalsis	IMP IMP: Inferred from mutant phenotype	12813150	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17074061	MGI
acts upstream of or within response to ATP	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	11069181	MGI
acts upstream of or within response to carbohydrate	IMP IMP: Inferred from mutant phenotype	16322458	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	15927378	MGI
acts upstream of or within response to heat	IMP IMP: Inferred from mutant phenotype	15927378	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	14672995	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	11466438	MGI
acts upstream of or within response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	11069182	MGI
acts upstream of or within sensory perception of taste	IGI IGI: Inferred from genetic interaction	16322458	MGI
acts upstream of or within urinary bladder smooth muscle contraction	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	11069181	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17074061	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17074061	MGI
located in axon	IDA IDA: Inferred from direct assay	11466438	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	17074061	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	17074061	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	11466438	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx3 Protein Structure

P2X_receptor

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 3

ATP receptor

purinergic receptor P2X3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09903	P2RX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09904	P2rx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09905	P2rx3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx3	NCBI	NCBI:5024

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