Vps18 - VPS18 CORVET/HOPS core subunit Gene

Mus musculus

Also known as 9930024E13Rik

Gene ID: 228545 | Gene type: protein coding

About Vps18

Summary

Enables actin binding activity. Acts upstream of or within endosome organization and viral entry into host cell. Located in actin filament and early endosome. Part of AP-3 adaptor complex and CORVET complex. Is expressed in alimentary system; ganglia; nose; and peripheral nervous system. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]

Vps18 Products(1)

mRNA	Protein	Name
NM_172269.3	NP_758473.3	vacuolar protein sorting-associated protein 18 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	14668490	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14668490	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within endosome organization	IDA IDA: Inferred from direct assay	14668490	MGI
acts upstream of or within symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	24550300	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of AP-3 adaptor complex	IDA IDA: Inferred from direct assay	21411634	MGI
part of CORVET complex	IDA IDA: Inferred from direct assay	25266290	MGI
located in actin filament	IDA IDA: Inferred from direct assay	14668490	MGI
located in early endosome	IDA IDA: Inferred from direct assay	14668490	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 18 homolog

vacuolar protein sorting 18

Vps18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Vps18	Q8R307	VIPAS39	Homo sapiens	Q9H9C1	Anti Tag CoIP	19109425
Cross	Vps18	Q8R307	VIPAS39	Homo sapiens	Q9H9C1	Anti Bait CoIP	19109425

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15677	VPS18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps18	NCBI	NCBI:57617

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