UBOX5 - U-box domain containing 5 Gene

Homo sapiens

Also known as UIP5; RNF37; hUIP5; UBCE7IP5

Gene ID: 22888 | Gene type: protein coding

About UBOX5

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,107,573-3,159,865 (from NCBI)

This gene has 3 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 Enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UBOX5 Products(3)

mRNA	Protein	Name
NM_001267584.2	NP_001254513.1	RING finger protein 37 isoform c
NM_014948.4	NP_055763.1	RING finger protein 37 isoform a
NM_199415.3	NP_955447.1	RING finger protein 37 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11274149	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear body	IDA IDA: Inferred from direct assay	11274149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBOX5 Protein Structure

U-box

0
100
200
300
400
500
541 a.a.

Protein Preferred Names

Protein Names

RING finger protein 37

RING-type E3 ubiquitin transferase RNF37

Related Diseases

Diseases

Alias

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Cdi
Pituitary Diabetes Insipidus	Vasopressin Defective Diabetes Insipidus
Vasopressin Deficiency	Central Diabetes Insipidus
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Mitochondrial Dna Depletion Syndrome 13

MTDPS13	Fbxl4 Deficiency
Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome	Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies	Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies
Fbxl4-Related Early-Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type
Bxl4-Related Early-Onset Mitochondrial Encephalopathy	Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13
Fbxl4-Related Early Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome, Type 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15381	UBOX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBOX5	VGNC	VGNC:66780
Macaca mulatta	UBOX5	VGNC	VGNC:98473
Canis familiaris	UBOX5	VGNC	VGNC:48083
Bos taurus	UBOX5	VGNC	VGNC:36612
Rattus norvegicus	UBOX5	RGD	RGD:1305440
Mus musculus	UBOX5	MGD	MGI:2154658

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