KHDC4 - KH domain containing 4, pre-mRNA splicing factor Gene

Homo sapiens

Also known as BLOM7; KIAA0907; SNORA80EHG

Gene ID: 22889 | Gene type: protein coding

About KHDC4

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,913,045-155,934,413 (from NCBI)

This gene has 10 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in lymph node (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splice site selection. Located in cytoplasm and nucleoplasm. Colocalizes with spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]

KHDC4 Products(1)

mRNA	Protein	Name
NM_014949.4	NP_055764.2	KH homology domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19641227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19641227	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splice site recognition	IDA IDA: Inferred from direct assay	19641227	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19641227	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19641227	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	19641227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

KH homology domain-containing protein 4

brings lots of money 7

KHDC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KHDC4	Q7Z7F0	RBM39	Homo sapiens	Q14498-3	Y2H Prey Pooling	25416956
Intra	KHDC4	Q7Z7F0	RBM39	Homo sapiens	Q14498-3	Validated Y2H	25416956
Intra	KHDC4	Q7Z7F0	RBM39	Homo sapiens	Q14498-3	Y2H Array	25416956
Intra	KHDC4	Q7Z7F0	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lip Cancer

Malignant Neoplasm Of Lip	Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Tumour Of Lip	Lip Neoplasms
Malignant Neoplasm Of Commissure Of Lip	Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower
Malignant Neoplasm Of Labial Commissure Of Lip	Malignant Neoplasm Of Lip, External
Malignant Neoplasm Of Lip, Inner Aspect	Malignant Neoplasm Of Lip, Vermilion Border
Malignant Neoplasm Of Lower Lip, Buccal Aspect	Malignant Neoplasm Of Lower Lip, Inner Aspect
Malignant Neoplasm Of Lower Lip, Mucosa	Malignant Neoplasm Of Lower Lip, Oral Aspect
Malignant Neoplasm Of Other Sites Of Lip	Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Tumor Of Commissure Of Lip	Malignant Tumor Of Labial Mucosa
Malignant Tumor Of Lip	Malignant Tumor Of Lower Labial Mucosa
Malignant Tumor Of The Lip	Malignant Tumour Of Labial Commissure
Cancer Of Lip	Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip
Upper Lip Cancer	Lower Lip Cancer
Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip	Primary Malignant Neoplasm Of Vermilion Border Of Lip
Malignant Neoplasm Of Lipstick Area Of Upper Lip	Malignant Neoplasm Of Upper Lip Nos
Malignant Neoplasm Of Vermilion Border Of Upper Lip	Malignant Neoplasm Of Lipstick Area Of Lower Lip
Malignant Neoplasm Of Lower Lip Nos	Malignant Neoplasm Of Vermilion Border Of Lower Lip
Malignant Neoplasm Of Vermilion Border Nos	Malignant Neoplasm Of Buccal Aspect Of Upper Lip
Malignant Neoplasm Of Frenulum Of Upper Lip	Malignant Neoplasm Of Mucosa Of Upper Lip
Malignant Neoplasm Of Oral Aspect Of Upper Lip	Malignant Neoplasm Of Buccal Aspect Of Lower Lip
Malignant Neoplasm Of Frenulum Of Lower Lip	Malignant Neoplasm Of Mucosa Of Lower Lip
Malignant Neoplasm Of Oral Aspect Of Lower Lip	Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower
Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower	Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower
Primary Malignant Neoplasm Of Commissure Of Lip	Primary Malignant Neoplasm Of Lip
Malignant Neoplasm Of Lip, Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07236	KHDC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KHDC4	VGNC	VGNC:63077
Macaca mulatta	KHDC4	VGNC	VGNC:73931
Canis familiaris	KHDC4	VGNC	VGNC:42354
Mus musculus	KHDC4	MGD	MGI:1921450
Bos taurus	KHDC4	VGNC	VGNC:30559
Rattus norvegicus	KHDC4	RGD	RGD:1565775

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