ZNF365 - zinc finger protein 365 Gene

Homo sapiens

Also known as UAN; Su48; ZNF365D

Gene ID: 22891 | Gene type: protein coding

About ZNF365

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,374,369-62,480,285 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in brain (RPKM 9.2), esophagus (RPKM 2.1) and 3 other tissues.

Summary

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast Cancer susceptibility. [provided by RefSeq, Mar 2020]

ZNF365 Products(2)

mRNA	Protein	Name
NM_014951.3	NP_055766.2	protein ZNF365 isoform A
NM_199450.3	NP_955522.1	protein ZNF365 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16617106	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16682949	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16617106	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within gamma-tubulin complex localization	IMP IMP: Inferred from mutant phenotype	16617106	GOA
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16617106	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	17389905	GOA
involved in regulation of DNA strand resection involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	23966166	GOA
involved in regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23966166	GOA
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	23776040	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	16617106	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein ZNF365

DISC1-binding zinc-finger protein

ZNF365 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF365	Q70YC5	NDE1	Homo sapiens	Q9NXR1	Y2H	16682949
Intra	ZNF365	Q70YC5	NDE1	Homo sapiens	Q9NXR1	IF	16682949

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To	Uric Acid Urolithiasis
Uric Acid Nephrolithiasis	UAN
Acute Urate Nephropathy	Urolithiasis, Uric Acid
Urolithiasis, Uric Acid, Susceptibility To	Uric Acid Renal Calculus

Narcolepsy 2

Narcolepsy 2, Susceptibility To	Narcolepsy Without Cataplexy
NRCLP2	Narcolepsy Type 2
Narcolepsy Without Cataplexy And Hypocretin Deficiency

Narcolepsy 1

NRCLP1	Narcoleptic Syndrome 1
Gelineau Disease	Narcolepsy-Cataplexy
Narcolepsy-Cataplexy Syndrome	Narcolepsy, Type 1
Narcolepsy Type 1	Cataplexy
Gélineau'S Syndrome	Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Mammographic Density

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Urolithiasis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Vogt-Koyanagi-Harada Disease

Uveomeningoencephalitic Syndrome	Uveomenigitic Syndrome
Vogt-Koyanagi-Harada Syndrome	Harada'S Disease
Vogt-Koyanagi Syndrome	Vkh Disease
Vkh Syndrome	Vkh

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16131	ZNF365 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZNF365	VGNC	VGNC:55088
Macaca mulatta	ZNF365	VGNC	VGNC:106123
Canis familiaris	ZNF365	VGNC	VGNC:48710
Mus musculus	ZNF365	MGD	MGI:2143676
Felis catus	ZNF365	VGNC	VGNC:67295

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