DIS3 - DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Gene

Homo sapiens

Also known as RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik

Gene ID: 22894 | Gene type: protein coding

About DIS3

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,752,169-72,781,900 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues.

Summary

Enables 3'-5'-exoribonuclease activity; Endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

DIS3 Products(4)

mRNA	Protein	Name
NM_001128226.3	NP_001121698.1	exosome complex exonuclease RRP44 isoform b
NM_001322348.2	NP_001309277.1	exosome complex exonuclease RRP44 isoform c
NM_001322349.2	NP_001309278.1	exosome complex exonuclease RRP44 isoform d
NM_014953.5	NP_055768.3	exosome complex exonuclease RRP44 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5'-RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	20531386	GOA
enables endonuclease activity	IMP IMP: Inferred from mutant phenotype	20531386	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9562621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CUT catabolic process	IMP IMP: Inferred from mutant phenotype	19056938	GOA
involved in RNA catabolic process	IDA IDA: Inferred from direct assay	17174896	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	17174896	GOA
involved in rRNA catabolic process	IMP IMP: Inferred from mutant phenotype	20368444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20531386	GOA
part of nuclear exosome (RNase complex)	IDA IDA: Inferred from direct assay	20531386	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	20531386	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20531389	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20531386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIS3 Protein Structure

PIN_4

RNB

0
200
400
600
800
958 a.a.

Protein Preferred Names

Protein Names

exosome complex exonuclease RRP44

DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

DIS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	Anti Bait CoIP	20531386
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	Anti Tag CoIP	33961781
Intra	DIS3	Q9Y2L1	EXOSC2	Homo sapiens	Q13868	TAP	20531386
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Bait CoIP	20531386
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	21255825
Intra	DIS3	Q9Y2L1	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	23756462
Intra	DIS3	Q9Y2L1	EXOSC3	Homo sapiens	Q9NQT5	Anti Tag CoIP	21255825

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Axenfeld-Rieger Syndrome, Type 2

Axenfeld-Rieger Syndrome Type 2	RIEG2
Rieger Syndrome, Type 2	Rieger Syndrome Type 2
Rieger Syndrome 2

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b	PCH1B
Pontocerebellar Hypoplasia 1b	Hypoplasia, Pontocerebellar, Type 1b

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance	Mgus
Mgus - [Monoclonal Gammopathy Of Undetermined Significance]	Monoclonal Gammopathy Nos
Iga Gammopathy	Monoclonal Gammoglobulinopathy

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Smoldering Myeloma

Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Colon Leiomyoma

Colonic Leiomyoma

Plasma Cell Leukemia

Plasma Cell Leukaemia	Leukemia, Plasma Cell
Plasmacytic Leukaemia	Plasmacytic Leukemia
Pcl	Plasma Cell Leukaemia, Nos
Leukemic Plasma Cell	Plasma Cell Leukaemia Without Mention Of Remission

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Nodular Malignant Melanoma

Nodular Melanoma

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03778	DIS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03779	DIS3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03780	DIS3L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DIS3	RGD	RGD:1304646
Canis familiaris	DIS3	VGNC	VGNC:39962
Mus musculus	DIS3	MGD	MGI:1919912
Bos taurus	DIS3	VGNC	VGNC:28072
Felis catus	DIS3	VGNC	VGNC:61499
Macaca mulatta	DIS3	VGNC	VGNC:71687

Name
Email *

	Sorry, but the email address you supplied was invalid.