ALDOB - aldolase, fructose-bisphosphate B Gene

Homo sapiens

Also known as ALDB; ALDO2

Gene ID: 229 | Gene type: protein coding

About ALDOB

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,420,560-101,435,774 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 2378.7), small intestine (RPKM 1833.7) and 2 other tissues.

Summary

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic Enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and Other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

ALDOB Products(1)

mRNA	Protein	Name
NM_000035.4	NP_000026.2	fructose-bisphosphate aldolase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	17576770	GOA
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	9244396	GOA
enables fructose binding	IMP IMP: Inferred from mutant phenotype	10625657	GOA
enables fructose-1-phosphate aldolase activity	IDA IDA: Inferred from direct assay	2649152	GOA
enables fructose-bisphosphate aldolase activity	IDA IDA: Inferred from direct assay	9244396	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10625657	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	35122041	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18000879	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADH oxidation	IDA IDA: Inferred from direct assay	17576770	GOA
involved in fructose 1,6-bisphosphate metabolic process	IDA IDA: Inferred from direct assay	9244396	GOA
involved in fructose metabolic process	IMP IMP: Inferred from mutant phenotype	3383242	GOA
involved in glycolytic process	IDA IDA: Inferred from direct assay	10625657	GOA
involved in negative regulation of pentose-phosphate shunt	IMP IMP: Inferred from mutant phenotype	35122041	GOA
involved in positive regulation of ATP-dependent activity	IGI IGI: Inferred from genetic interaction	17576770	GOA
involved in vacuolar proton-transporting V-type ATPase complex assembly	IGI IGI: Inferred from genetic interaction	17576770	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	18000879	GOA
located in cytosol	IDA IDA: Inferred from direct assay	35122041	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	18000879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDOB Protein Structure

Glycolytic

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

fructose-bisphosphate aldolase B

aldolase 2

ALDOB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALDOB	P05062	BBS1	Homo sapiens	Q8NFJ9	CoIP	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	Y2H	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	Confocal	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	CoIP	18000879
Intra	ALDOB	P05062	BBS7	Homo sapiens	Q8IWZ6	Confocal	18000879
Intra	ALDOB	P05062	BBS7	Homo sapiens	Q8IWZ6	CoIP	18000879
Intra	ALDOB	P05062	ALDOA	Homo sapiens	P04075	Anti Tag CoIP	33961781
Intra	ALDOB	P05062	ALDOA	Homo sapiens	P04075	Y2H	21988832
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	CoIP	18000879
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	Confocal	18000879
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	Y2H	18000879

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDOB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74419	Aldolase B Protein, Human (GST)	P05062 (A2-Y364)	≥95%

Related Diseases

Diseases

Alias

Fructose Intolerance, Hereditary

Hereditary Fructose Intolerance	Fructose Intolerance
Fructose-1-Phosphate Aldolase Deficiency	Fructose-1,6-Bisphosphate Aldolase B Deficiency
Aldolase B Deficiency	Fructosemia
Aldob Deficiency	Hereditary Fructose Intolerance Syndrome
HFI	Fructosaemia
Hereditary Fructose-1-Phosphate Aldolase Deficiency	Fructose Aldolase B Deficiency
Fructose-1,6-Biphosphate Aldolase Deficiency	Hereditary Fructosemia
Fructosemia, Hereditary	Hereditary Fructosaemia
Fructose-Biphosphate Aldolase B Deficiency	Fructose Intolerance Of Newborn
Aldb - [Aldolase B] Deficiency	Deficiency Of Fructose-Bisphosphate Aldolase

Fructosuria, Essential

Essential Fructosuria	Ketohexokinase Deficiency
Fructosuria	Hepatic Fructokinase Deficiency
Fructokinase Deficiency	FRUCT
Deficiency Of Fructokinase

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00584	ALDOB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALDOB	VGNC	VGNC:69791
Felis catus	ALDOB	VGNC	VGNC:59740
Bos taurus	ALDOB	VGNC	VGNC:25822
Canis familiaris	ALDOB	VGNC	VGNC:37792
Rattus norvegicus	ALDOB	RGD	RGD:2090
Mus musculus	ALDOB	MGD	MGI:87995
Others	ALDOB	NCBI

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