2. Gene
  3. SCMH1 - Scm polycomb group protein homolog 1 Gene

SCMH1 - Scm polycomb group protein homolog 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Scml3

Gene ID: 22955 | Gene type: protein coding

About SCMH1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,027,202-41,242,306 (from NCBI)

This gene has 15 transcripts (splice variants), 222 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 14.6), ovary (RPKM 12.4) and 25 other tissues.

Summary

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within anterior/posterior pattern specification; chromatin remodeling; and spermatogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SCMH1 Products(21)

mRNA Protein Name
NM_001031694.3 NP_001026864.1 polycomb protein SCMH1 isoform a
NM_001172218.2 NP_001165689.1 polycomb protein SCMH1 isoform c
NM_001172219.2 NP_001165690.1 polycomb protein SCMH1 isoform d
NM_001172220.2 NP_001165691.1 polycomb protein SCMH1 isoform c
NM_001172221.3 NP_001165692.1 polycomb protein SCMH1 isoform e
NM_001172222.3 NP_001165693.1 polycomb protein SCMH1 isoform f
NM_001350667.2 NP_001337596.1 polycomb protein SCMH1 isoform g
NM_001350668.2 NP_001337597.1 polycomb protein SCMH1 isoform h
NM_001394299.1 NP_001381228.1 polycomb protein SCMH1 isoform i
NM_001394300.1 NP_001381229.1 polycomb protein SCMH1 isoform a
NM_001394301.1 NP_001381230.1 polycomb protein SCMH1 isoform a
NM_001394302.1 NP_001381231.1 polycomb protein SCMH1 isoform a
NM_001394303.1 NP_001381232.1 polycomb protein SCMH1 isoform e
NM_001394304.1 NP_001381233.1 polycomb protein SCMH1 isoform i
NM_001394305.1 NP_001381234.1 polycomb protein SCMH1 isoform i
NM_001394306.1 NP_001381235.1 polycomb protein SCMH1 isoform i
NM_001394307.1 NP_001381236.1 polycomb protein SCMH1 isoform j
NM_001394308.1 NP_001381237.1 polycomb protein SCMH1 isoform k
NM_001394309.1 NP_001381238.1 polycomb protein SCMH1 isoform l
NM_001394311.1 NP_001381240.1 polycomb protein SCMH1 isoform m
NM_012236.4 NP_036368.1 polycomb protein SCMH1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCMH1 Protein Structure

MBT

MBT: mbt repeat (62 - 132)

MBT

MBT: mbt repeat (171 - 236)

SLED

SLED: SLED domain (356 - 469)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (591 - 656)

  • 0
  • 200
  • 400
  • 600
  • 660 a.a.
Protein Preferred Names Protein Names

polycomb protein SCMH1

sex comb on midleg homolog 1

SCMH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SCMH1 Q96GD3 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
SCMH1 Q96GD3 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
SCMH1 Q96GD3 SFMBT2 Homo sapiens Q5VUG0
Y2H Array
32296183
Intra
SCMH1 Q96GD3 SFMBT2 Homo sapiens Q5VUG0
Y2H Prey Pooling
32296183
Intra
SCMH1 Q96GD3 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
SCMH1 Q96GD3 HPCAL4 Homo sapiens Q9UM19
Validated Y2H
32296183
Intra
SCMH1 Q96GD3 HPCAL4 Homo sapiens Q9UM19
Y2H Prey Pooling
32296183
Intra
SCMH1 Q96GD3 HPCAL4 Homo sapiens Q9UM19
Y2H Array
32296183
Intra
SCMH1 Q96GD3 SFMBT1 Homo sapiens Q9UHJ3
Y2H Prey Pooling
32296183
Intra
SCMH1 Q96GD3 SFMBT1 Homo sapiens Q9UHJ3
Validated Y2H
32296183
Intra
SCMH1 Q96GD3 SFMBT1 Homo sapiens Q9UHJ3
Y2H Array
32296183
Intra
SCMH1 Q96GD3 MAGEA12 Homo sapiens P43365
Y2H Array
25416956
Intra
SCMH1 Q96GD3 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
25416956
Intra
SCMH1 Q96GD3 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12515 SCMH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SCMH1 VGNC VGNC:64916
Canis familiaris SCMH1 VGNC VGNC:45910
Mus musculus SCMH1 MGD MGI:1352762
Bos taurus SCMH1 VGNC VGNC:34340
Macaca mulatta SCMH1 VGNC VGNC:77051
Rattus norvegicus SCMH1 RGD RGD:1305788