MAGEA12 - MAGE family member A12 Gene

Homo sapiens

Also known as CT1.12; MAGE12

Gene ID: 4111 | Gene type: protein coding

About MAGEA12

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,733,757-152,737,669 (from NCBI)

This gene has 3 transcripts (splice variants), 459 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 1.8).

Summary

This gene is closely related to several Other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

MAGEA12 Products(3)

mRNA	Protein	Name
NM_001166386.3	NP_001159858.1	melanoma-associated antigen 12
NM_001166387.4	NP_001159859.1	melanoma-associated antigen 12
NM_005367.7	NP_005358.2	melanoma-associated antigen 12

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEA12 Protein Structure

MAGE_N

MAGE

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen 12

MAGE12F antigen

MAGEA12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAGEA12	P43365	NANOS2	Homo sapiens	P60321	Validated Y2H	32296183
Intra	MAGEA12	P43365	NANOS2	Homo sapiens	P60321	Y2H Array	25416956
Intra	MAGEA12	P43365	NANOS2	Homo sapiens	P60321	Y2H Array	31515488
Intra	MAGEA12	P43365	FASTKD3	Homo sapiens	Q14CZ7	Validated Y2H	25416956
Intra	MAGEA12	P43365	MTFR2	Homo sapiens	Q6P444	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	MTFR2	Homo sapiens	Q6P444	Y2H Array	25416956
Intra	MAGEA12	P43365	POLL	Homo sapiens	Q9UGP5-2	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	MAGEA12	P43365	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	25416956
Intra	MAGEA12	P43365	POLL	Homo sapiens	Q9UGP5-2	Y2H Array	25416956
Intra	MAGEA12	P43365	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	MAGEA12	P43365	TBC1D19	Homo sapiens	Q8N5T2	Y2H Array	25416956
Intra	MAGEA12	P43365	TBC1D19	Homo sapiens	Q8N5T2	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	MAGEA12	P43365	MTFR1L	Homo sapiens	Q9H019	Validated Y2H	25416956
Intra	MAGEA12	P43365	ZNF33B	Homo sapiens	Q06732	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	CLIP4	Homo sapiens	Q8N3C7	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	CLIP4	Homo sapiens	Q8N3C7	Validated Y2H	25416956
Intra	MAGEA12	P43365	CLIP4	Homo sapiens	Q8N3C7	Validated Y2H	32296183
Intra	MAGEA12	P43365	CLIP4	Homo sapiens	Q8N3C7	Y2H Array	25416956
Intra	MAGEA12	P43365	C16orf87	Homo sapiens	Q6PH81	Validated Y2H	32296183
Intra	MAGEA12	P43365	C16orf87	Homo sapiens	Q6PH81	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	C16orf87	Homo sapiens	Q6PH81	Validated Y2H	25416956
Intra	MAGEA12	P43365	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
Intra	MAGEA12	P43365	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	MAGEA12	P43365	HK2	Homo sapiens	P52789	Validated Y2H	25416956
Intra	MAGEA12	P43365	HK2	Homo sapiens	P52789	Y2H Array	25416956
Intra	MAGEA12	P43365	ABI3	Homo sapiens	Q9P2A4	Y2H Array	25416956
Intra	MAGEA12	P43365	FNDC11	Homo sapiens	Q9BVV2	Y2H Prey Pooling	25416956
Intra	MAGEA12	P43365	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	25416956
Intra	MAGEA12	P43365	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
Intra	MAGEA12	P43365	NPPA	Homo sapiens	P01160	Y2H Array	25416956
Intra	MAGEA12	P43365	NPPA	Homo sapiens	P01160	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2269	MAIT-203		/	Unkown
HY-RS07966	MAGEA12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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