KDM2A - lysine demethylase 2A Gene

Homo sapiens

Also known as FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA

Gene ID: 22992 | Gene type: protein coding

About KDM2A

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,119,263-67,258,082 (from NCBI)

This gene has 15 transcripts (splice variants), 296 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 25.2), bone marrow (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

KDM2A Products(2)

mRNA	Protein	Name
NM_001256405.2	NP_001243334.1	lysine-specific demethylase 2A isoform b
NM_012308.3	NP_036440.1	lysine-specific demethylase 2A isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K36 demethylase activity	IMP IMP: Inferred from mutant phenotype	20417597	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15070733	GOA
enables unmethylated CpG binding	IDA IDA: Inferred from direct assay	29276034	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29276034	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26037310	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	21187428	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	26037310	GOA
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	26037310	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM2A Protein Structure

JmjC

zf-CXXC

F-box

0
200
400
600
800
1000
1162 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 2A

CXXC-type zinc finger protein 8

KDM2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KDM2A	Q9Y2K7	SKP1	Homo sapiens	P63208	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

KDM2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83067	KDM2A Antibody (YA2812)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases

Alias

Duodenum Adenoma

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12304	IOX1	Inhibitor	99.72%	Unkown
HY-13643	Daminozide	Inhibitor	99.79%	Unkown
HY-108706	KDM2A/7A-IN-1	Inhibitor	99.94%	Unkown
HY-107573	KDM2/7-IN-1	Inhibitor	99.00%	Unkown
HY-RS07209	KDM2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KDM2A	MGD	MGI:1354736
Bos taurus	KDM2A	VGNC	VGNC:56269
Macaca mulatta	KDM2A	VGNC	VGNC:73824
Rattus norvegicus	KDM2A	RGD	RGD:1309419
Canis familiaris	KDM2A	VGNC	VGNC:42320
Felis catus	KDM2A	VGNC	VGNC:63069
Others	KDM2A	NCBI

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