2. Epigenetics
  3. Histone Demethylase
  4. KDM2/7-IN-1

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

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KDM2/7-IN-1 Chemical Structure

KDM2/7-IN-1 Chemical Structure

CAS No. : 1453071-47-0

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Based on 1 publication(s) in Google Scholar

KDM2/7-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KDM2/7-IN-1

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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  • Purity & Documentation

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Description

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

IC50 & Target

KDM2

 

KDM4

 

KDM7

 

Cellular Effect
Cell Line Type Value Description References
HeLa GI50
40 μM
Compound: 9
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 23964788]
KYSE-150 cell line GI50
16 μM
Compound: 9
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay
[PMID: 23964788]
N2a GI50
86 μM
Compound: 9
Growth inhibition of mouse N2A cells after 48 hrs by MTT assay
Growth inhibition of mouse N2A cells after 48 hrs by MTT assay
[PMID: 23964788]
In Vitro

KDM2/7-IN-1 (50 μM, 24 hours) significantly increases H3K27me2 levels in N2a cells[1].
KDM2/7-IN-1 (GI50: 40 μM, 16 μM, 48 hours) significantly inhibits the proliferation of HeLa and KYSE150 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KDM2/7-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: N2a cells (mouse neuroblastoma)
Concentration: 10 μM and 50 μM
Incubation Time: 24 hours
Result: Significantly increased H3K27me2 levels in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: HeLa and KYSE150 cells (cervical and esophageal cancer)
Concentration: 16 μM and 40 μM
Incubation Time: 48 hours
Result: Significantly inhibited proliferation of HeLa and KYSE150 cells.
Molecular Weight

285.38

Formula

C15H27NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCN(O)C(CCCCCCCCC1CC1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (105.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5041 mL 17.5205 mL 35.0410 mL
5 mM 0.7008 mL 3.5041 mL 7.0082 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5041 mL 17.5205 mL 35.0410 mL 87.6025 mL
5 mM 0.7008 mL 3.5041 mL 7.0082 mL 17.5205 mL
10 mM 0.3504 mL 1.7520 mL 3.5041 mL 8.7602 mL
15 mM 0.2336 mL 1.1680 mL 2.3361 mL 5.8402 mL
20 mM 0.1752 mL 0.8760 mL 1.7520 mL 4.3801 mL
25 mM 0.1402 mL 0.7008 mL 1.4016 mL 3.5041 mL
30 mM 0.1168 mL 0.5840 mL 1.1680 mL 2.9201 mL
40 mM 0.0876 mL 0.4380 mL 0.8760 mL 2.1901 mL
50 mM 0.0701 mL 0.3504 mL 0.7008 mL 1.7520 mL
60 mM 0.0584 mL 0.2920 mL 0.5840 mL 1.4600 mL
80 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0950 mL
100 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8760 mL
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KDM2/7-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDM2/7-IN-11453071-47-0Histone DemethylaseN2a cells (mouse neuroblastoma)Anti-cancerInhibitorinhibitorinhibit

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