ALDOC - aldolase, fructose-bisphosphate C Gene

Homo sapiens

Also known as ALDC

Gene ID: 230 | Gene type: protein coding

About ALDOC

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,573,120-28,576,895 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in brain (RPKM 270.0), fat (RPKM 67.7) and 5 other tissues.

Summary

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic Enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

ALDOC Products(1)

mRNA	Protein	Name
NM_005165.3	NP_005156.1	fructose-bisphosphate aldolase C

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	9244396	GOA
enables fructose-bisphosphate aldolase activity	IDA IDA: Inferred from direct assay	9244396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11399750	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in fructose 1,6-bisphosphate metabolic process	IDA IDA: Inferred from direct assay	9244396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDOC Protein Structure

Glycolytic

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

fructose-bisphosphate aldolase C

aldolase 3

ALDOC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALDOC	P09972	ALDOA	Homo sapiens	P04075-2	Y2H Prey Pooling	25416956
Intra	ALDOC	P09972	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	ALDOC	P09972	ALDOA	Homo sapiens	P04075	Anti Tag CoIP	33961781
Intra	ALDOC	P09972	ALDOA	Homo sapiens	P04075	Anti Tag CoIP	28514442
Intra	ALDOC	P09972	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDOC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7478	Aldolase C Protein, Human (HEK293, His)	P09972 (P2-Y364)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00585	ALDOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ALDOC	VGNC	VGNC:59741
Macaca mulatta	ALDOC	VGNC	VGNC:69792
Bos taurus	ALDOC	VGNC	VGNC:25823
Mus musculus	ALDOC	MGD	MGI:101863
Rattus norvegicus	ALDOC	RGD	RGD:2091
Canis familiaris	ALDOC	VGNC	VGNC:37793
Others	ALDOC	NCBI

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