1. Gene
  2. RAB21 - RAB21, member RAS oncogene family Gene

RAB21 - RAB21, member RAS oncogene family Gene

Homo sapiens
Gene ID: 23011 | Gene type: protein coding

About RAB21

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,754,863-71,800,286 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 10.9), adrenal (RPKM 10.2) and 25 other tissues.

Summary

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with Integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

RAB21 Products(1)

mRNA Protein Name
NM_014999.4 NP_055814.1 ras-related protein Rab-21
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
16034420 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
16034420 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
15561770 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
16034420 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16525121 GOA
Biological Process GO Annotation Evidence Reference Source
involved in anterograde axonal transport IDA
IDA: Inferred from direct assay
22705394 GOA
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
22705394 GOA
involved in positive regulation of early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
15561770 GOA
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15561770 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
31455601 GOA
involved in regulation of exocytosis IDA
IDA: Inferred from direct assay
22705394 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi cisterna membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in cytoplasmic side of early endosome membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
15561770 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19745841 GOA
located in vesicle membrane IDA
IDA: Inferred from direct assay
15561770 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB21 Protein Structure

Ras

Ras: Ras family (21 - 181)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-21

GTP-binding protein RAB21

RAB21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RAB21 Q9UL25 APPL1 Homo sapiens Q9UKG1 17581628
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carpenter Syndrome 1

Carpenter Syndrome

Acrocephalopolysyndactyly Type Ii

Acps Ii

CRPT1

Acrocephalopolysyndactyly Type 2

Acrocephalosyndactyly, Type Ii

Acrocephalopolysyndactyly 2

Acps2

Acps 2

Type Ii Acrocephalosyndactyly

Carpenter Syndrome, Type 1

Apert-Crouzon Disease

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2

CMT2E

CMT2S

CMT2Y

Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease Axonal Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2s

Charcot-Marie-Tooth Disease, Type 2e

Hereditary Motor And Sensory Neuropathy Type 2

Charcot-Marie-Tooth Neuropathy, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2y

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y

Charcot-Marie-Tooth Neuropathy, Type 2y

Charcot-Marie-Tooth Disease, Type 2y

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Neuropathy Type 2e

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation

Cmt2 Due To Vcp Mutation

Charcot-Marie-Tooth Disease Type 2s

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease

Cmt2

Charcot-Marie-Tooth Neuropathy, Type 2e

Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type

Hereditary Motor And Sensory Neuropathy Okinawa Type

Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y

Charcot-Marie-Tooth Neuropathy Type 2y

Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s

Charcot-Marie-Tooth Neuropathy Type 2s

Charcot-Marie-Tooth Type 2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease 2e

Charcot-Marie-Tooth Disease Axonal Type 2e

Charcot-Marie-Tooth Disease Neuronal Type 2e

Charcot-Marie-Tooth Disease 2s

Charcot-Marie-Tooth Neuropathy Axonal Type 2s

Charcot-Marie-Tooth Disease 2y

Charcot-Marie-Tooth Disease, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Charcot-Marie-Tooth Disease, Type 4b2

Charcot-Marie-Tooth Disease Type 4b2

CMT4B2

Charcot-Marie-Tooth Disease, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b2

Charcot-Marie-Tooth Neuropathy, Type 4b2

Charcot-Marie-Tooth Neuropathy Type 4b2

Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b2

Cmt 4b2

Charcot Marie Tooth Disease Type 4b2

Charcot-Marie-Tooth Disease 4b2

Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b2

Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b2

Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus RAB21 VGNC VGNC:33628
Rattus norvegicus RAB21 RGD RGD:1303150
Macaca mulatta RAB21 VGNC VGNC:100097
Mus musculus RAB21 MGD MGI:894308
Canis familiaris RAB21 VGNC VGNC:45261