Dok7 - docking protein 7 Gene

Mus musculus

Also known as Oit5; Dok-7; EF-12; A930013K19Rik

Gene ID: 231134 | Gene type: protein coding

About Dok7

Summary

Enables phosphatidylinositol binding activity and protein kinase binding activity. Involved in positive regulation of protein tyrosine kinase activity. Acts upstream of or within neuromuscular junction development; positive regulation of protein phosphorylation; and receptor clustering. Located in neuromuscular junction. Is expressed in several structures, including central nervous system; heart; skeletal muscle; and testis. Used to study congenital myasthenic syndrome 10. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Dok7 Products(5)

mRNA	Protein	Name
NM_001348274.1	NP_001335203.1	protein Dok-7 isoform 2
NM_001348275.1	NP_001335204.1	protein Dok-7 isoform 3
NM_001348276.1	NP_001335205.1	protein Dok-7 isoform 4
NM_001348478.1	NP_001335407.1	protein Dok-7 isoform 1
NM_172708.4	NP_766296.1	protein Dok-7 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	20603078	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16794080	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	20603078	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16794080	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in enzyme-linked receptor protein signaling pathway	IDA IDA: Inferred from direct assay	18848351	MGI
involved in enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in enzyme-linked receptor protein signaling pathway	IMP IMP: Inferred from mutant phenotype	14622576	MGI
acts upstream of or within neuromuscular junction development	IDA IDA: Inferred from direct assay	16794080	MGI
acts upstream of or within neuromuscular junction development	IGI IGI: Inferred from genetic interaction	16794080	MGI
involved in positive regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	16794080	MGI
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	16794080	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16794080	MGI
involved in positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	20603078	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	18848351	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	14622576	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16794080	MGI
acts upstream of or within receptor clustering	IDA IDA: Inferred from direct assay	16794080	MGI
acts upstream of or within receptor clustering	IGI IGI: Inferred from genetic interaction	16794080	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	14622576	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	16794080	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16794080	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Dok-7

downstream of tyrosine kinase 7

oncoprotein induced transcript 5

Dok7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dok7	Q18PE0	Musk	Mus musculus	Q61006	Pull Down	20371544
Intra	Dok7	Q18PE0	Musk	Mus musculus	Q61006	ITC	20603078

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03939	DOK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dok7	NCBI	NCBI:285489

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