1. Gene
  2. FLG - filaggrin Gene

FLG - filaggrin Gene

Homo sapiens

Also known as FLG1; ATOD2; FLG-1

Gene ID: 2312 | Gene type: protein coding

About FLG

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,302,165-152,325,239 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward skin (RPKM 454.2).

Summary

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]

FLG Products(1)

mRNA Protein Name
NM_002016.2 NP_002007.1 filaggrin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23629652 GOA
enables structural constituent of skin epidermis IDA
IDA: Inferred from direct assay
7543090 GOA
Biological Process GO Annotation Evidence Reference Source
involved in establishment of skin barrier IEP
IEP: Inferred from expression pattern
23403047 GOA
involved in peptide cross-linking IDA
IDA: Inferred from direct assay
7543090 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cornified envelope IDA
IDA: Inferred from direct assay
7543090 GOA
located in keratohyalin granule IDA
IDA: Inferred from direct assay
1429717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLG Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (4 - 47)

Filaggrin

Filaggrin: Filaggrin (258 - 306)

Filaggrin

Filaggrin: Filaggrin (374 - 428)

Filaggrin

Filaggrin: Filaggrin (579 - 630)

Filaggrin

Filaggrin: Filaggrin (698 - 753)

Filaggrin

Filaggrin: Filaggrin (904 - 955)

Filaggrin

Filaggrin: Filaggrin (1023 - 1077)

Filaggrin

Filaggrin: Filaggrin (1228 - 1279)

Filaggrin

Filaggrin: Filaggrin (1347 - 1401)

Filaggrin

Filaggrin: Filaggrin (1552 - 1603)

Filaggrin

Filaggrin: Filaggrin (1671 - 1725)

Filaggrin

Filaggrin: Filaggrin (1876 - 1927)

Filaggrin

Filaggrin: Filaggrin (1995 - 2050)

Filaggrin

Filaggrin: Filaggrin (2201 - 2252)

Filaggrin

Filaggrin: Filaggrin (2320 - 2374)

Filaggrin

Filaggrin: Filaggrin (2525 - 2576)

Filaggrin

Filaggrin: Filaggrin (2644 - 2698)

Filaggrin

Filaggrin: Filaggrin (2849 - 2900)

Filaggrin

Filaggrin: Filaggrin (2968 - 3022)

Filaggrin

Filaggrin: Filaggrin (3173 - 3224)

Filaggrin

Filaggrin: Filaggrin (3292 - 3346)

Filaggrin

Filaggrin: Filaggrin (3497 - 3548)

Filaggrin

Filaggrin: Filaggrin (3616 - 3670)

Filaggrin

Filaggrin: Filaggrin (3821 - 3870)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4061 a.a.
Protein Preferred Names Protein Names

filaggrin

epidermal filaggrin

Recombinant FLG Proteins

Cat. No. Product Name Accession Purity
HY-P71734 FLG Protein, Human (P.pastoris, His) P20930 (D3838-E4061) ≥95%

Related Diseases

Diseases Alias
Dermatitis, Atopic, 2

Atopic Dermatitis 2

ATOD2

Dermatitis, Atopic, Susceptibility To, 2

Dermatitis, Atopic, 2, Susceptibility To

Dermatitis, Atopic 2

Dermatitis Atopic 2

Atopic Eczema

Dermatitis, Atopic, Type 2

Dermatitis, Atopic

Ichthyosis Vulgaris

Ichthyosis Simplex

Dominant Congenital Ichthyosiform Erythroderma

Common Ichthyosis

Fish Scale Disease

VI

Ichthyoses

Congenital Ichthyosis

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Paroxysmal Dystonia

Paroxysmal Dyskinesia

Pxd - [Paroxysmal Dyskinesia]

Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis

Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay

CHEGDD

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Keratosis

Actinic Keratosis

Hyperkeratosis

Ichthyosis, X-Linked

X-Linked Ichthyosis

Steroid Sulfatase Deficiency

Placental Steroid Sulfatase Deficiency

Steroid Sulfatase Deficiency Disease

XLI

Sts Deficiency

Ssdd

X-Linked Recessive Ichthyosis

X-Linked Ichthyosis With Steryl-Sulphatase Deficiency

X-Linked Placental Steryl-Sulphatase Deficiency

Ssd

X Linked Ichthyosis

Recessive X-Linked Ichthyosis

Rxli

Syndromic Recessive X-Linked Ichthyosis

Recessive X-Linked Ichthyosis With Extracutaneous Manifestations

Syndromic Rxli

X-Linked Ichthyosis Syndrome

IXL

Ichthyosis X-Linked

Sex-Linked Ichthyosis

X-Linked Ichthyosis With Steryl-Sulfatase Deficiency

Lichen Planus

Lichen Ruber Planus

Lichen, Ruber Planus

Ruber Planus

Lp - [Lichen Planus]

Lichen Planus Of Wilson

Wilson Lichen Ruber

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis

Autosomal Recessive Congenital Ichthyosis 4b

Hi

Harlequin Fetus

ARCI4B

Ichthyosis Congenita, Harlequin Fetus Type

Harlequin Type Ichthyosis

'Harlequin Fetus'

Harlequin Type Ichthyosis Congenita

Harlequin Type Ichthyosis Fetalis

Harlequin Baby Syndrome

Ichthyosis Congenita, Harlequin Type

Ichthyosis Fetalis, Harlequin Type

Ichthyosis Congenita Harlequin Fetus Type

Ichthyosis, Harlequin

Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset

Irritant Dermatitis

Irritant Contact Dermatitis

Primary Irritant Dermatitis

Dermatitis, Irritant

Contact Dermatitis, Irritant

Irritant Contact Eczema

Icd - [Irritant Contact Dermatitis]

Irritant Contact Dermatitis, Unspecified Cause

Non-Allergic Contact Dermatitis

Irritant Contact Eczema Due To Wet Work

Irritant Contact Dermatitis Due To Detergents

Irritant Contact Eczema Due To Solvents

Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

Irritant Contact Eczema Due To Cosmetics Or Emollients

Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

Irritant Contact Eczema Due To Foods

Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

Irritant Contact Eczema Due To Saliva

Irritant Contact Eczema Due To Incontinence

Incontinence-Associated Dermatitis

Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome

Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa

Epidermolysis Bullosa Dystrophica

Dystrophic Epidermolysis Bullosa

Deb

Dermolytic Epidermolysis Bullosa

Epidermolysis Bullosa, Dermolytic

Epidermolysis Bullosa, Dystrophic

Epidermolysis Bullosa Dystrophic

Dystrophic Eb - [Epidermolysis Bullosa]

Occupational Dermatitis

Dermatitis, Occupational

Occupational Allergic Contact Dermatitis

Occupational Eczema

Eczema Herpeticum

Herpes Simplex Dermatitis

Herpes Simplex Eyelid Dermatitis

Kaposi Varicelliform Eruption

Herpes Simplex Dermatitis Of Eyelid

Herpes Simplex Virus Dermatitis

Herpes Simplex Virus Eyelid Dermatitis

Neurodermatitis
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Epidermolysis Bullosa

Acantholysis Bullosa

Eb

Legume Allergy

Fabaceae Allergy

Fruit Allergy

Allergy To Fruit

Dermatitis, Atopic, 4

ATOD4

Dermatitis, Atopic, Susceptibility To, 4

Atopic Dermatitis 4

Dermatitis, Atopic 4

Papilloma

Papillomatosis

Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1

Leukoplakia

Leukoplakia Of Gingiva

Leukoplakia Of Oral Epithelium

Leucoplakia Of Oral Mucosa

Leukokeratosis Of Oral Mucosa

Esophagitis

Acute Esophagitis

Chicken Egg Allergy

Gallus Gallus Egg Allergy

Peanut Allergy

Allergy To Peanuts

Peanut Allergic Reaction

Allergies Peanut

Peanut Hypersensitivity

Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma

Psoriasis
Nut Allergy

Nut Allergic Reaction

Nut Hypersensitivity

Allergy To Nuts

Allergy Nut

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Acne

Acne Vulgaris

Acne Varioliformis

Frontalis Acne

Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade

Rhinitis

Runny Nose

Corticosteroid Allergy
Hypotrichosis
Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Egg Allergy

Allergy To Eggs

Allergies Egg

Egg Hypersensitivity

Nasal Cavity Disease

Disorder Of Nasal Cavity

Seborrheic Dermatitis

Seborrhoeic Dermatitis

Seborrhea

Seborrhoeic Eczema

Skin Seborrheic

Dermatitis, Seborrheic

Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Clear Cell Acanthoma

Acanthoma

Pale Acanthoma

Acanthoma, Clear Cell

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Skin Atrophy

Atrophic Condition Of Skin

Atrophoderma

Atrophy - Skin

Metal Allergy
Alopecia
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset

Mite Infestation

Mite Infestations

Acariasis

Infestation By Mites Nos

Photoallergic Dermatitis

Dermatitis, Photoallergic

Photoallergic Contact Dermatitis

Photoallergic Eczema

Photo-Allergic Contact Eczema

Integumentary System Disease
Peeling Skin Syndrome

Deciduous Skin

Familial Continuous Skin Peeling Syndrome

Idiopathic Deciduous Skin

Keratosis Exfoliativa Congenita

Pss

Peeling Skin Disease

Skin Peeling Syndrome

Familial Continuous Skin Peeling

Keratolysis Exfoliativa Congenita

Exfoliation Syndrome

Keratolysis Exfoliativa

Cicatricial Lagophthalmos
Respiratory Allergy

Airway Allergy

Human Papillomavirus Infectious Disease

Hpv

Papillomavirus Infections

Human Papilloma Virus Infection

Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity

Scabies

Sarcoptic Itch

Infestation By Sarcoptes Scabiei

Infestation By Sarcoptes Scabiei Var Hominis

Infestation By Sarcoptes Scabiei Var. Hominis

Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee

Actinic Keratosis

Solar Keratosis

Actinic Keratosis

Senile Hyperkeratosis

Sk - Solar Keratosis

Keratosis, Actinic

Seborrheic Keratosis

Ak - [Actinic Keratosis]

Sk - [Solar Keratosis]

Seborrheic Infantile Dermatitis

Cradle Cap

Infantile Seborrhoeic Dermatitis

Seborrhoea Capitis

Seborrhoeic Dermatitis Of Scalp

Seborrhoeic Eczema Of Scalp

Complement 5 Dysfunction

Generalized Seborrheic Dermatitis Of Infants

Infantile Seborrheic Dermatitis

Pityriasis Capitis

Seborrhea Capitis

Seborrhea Sicca

Dandruff

Complement Component 5 Deficiency

Seborrheic Dermatitis

Seborrheic Dermatitis Of Scalp

Scurfiness Of Scalp

Seborrheic Dermatitis Of Infancy

Infantile Seborrhoeic Eczema

Neonatal Seborrhoeic Dermatitis

Infantile Seborrhoeic Dermatitis Of The Scalp

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma

Sebaceous Gland Disease

Sebaceous Gland Anomaly

Sebaceous Gland Diseases

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Autoimmune Disease Of Skin And Connective Tissue
Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Hair Disease

Hair Diseases

Hair Anomaly

Hair Disorder

Hair Problems

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FLG RGD RGD:2620
Others FLG NCBI