STAB1 - stabilin 1 Gene

Homo sapiens

Also known as FEX1; FEEL1; FEEL-1; FELE-1; SCARH2; STAB-1; CLEVER-1

Gene ID: 23166 | Gene type: protein coding

About STAB1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,495,338-52,524,495 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 2 paralogues. Broad expression in spleen (RPKM 55.7), placenta (RPKM 32.7) and 21 other tissues.

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

STAB1 Products(1)

mRNA	Protein	Name
NM_015136.3	NP_055951.2	stabilin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	12077138	GOA
enables low-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	12077138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16357325	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	12077138	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	12077138	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	12077138	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	12077138	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12077138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAB1 Protein Structure

Fasciclin

EGF_3

Fasciclin

EGF_3

Fasciclin

EGF_3

Xlink

0
400
800
1200
1600
2000
2400
2570 a.a.

Protein Preferred Names

Protein Names

stabilin-1

MS-1 antigen

STAB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STAB1	Q9NY15	FN1	Homo sapiens	P02751	Y2H	34968453
Intra	STAB1	Q9NY15	FN1	Homo sapiens	P02751	Pull Down	34968453

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Histiocytosis

Chronic Histiocytosis X	Hand Schuller Christian Disease
Hand-Schüller-Christian Disease	Histiocytic Syndrome
Histiocytosis, Langerhans-Cell

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13861	STAB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STAB1	MGD	MGI:2178742
Rattus norvegicus	STAB1	RGD	RGD:2324745
Bos taurus	STAB1	VGNC	VGNC:35348
Macaca mulatta	STAB1	VGNC	VGNC:77956
Canis familiaris	STAB1	VGNC	VGNC:54368
Felis catus	STAB1	VGNC	VGNC:65739

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