PSME4 - proteasome activator subunit 4 Gene

Homo sapiens

Also known as PA200

Gene ID: 23198 | Gene type: protein coding

About PSME4

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,864,069-53,970,993 (from NCBI)

This gene has 9 transcripts (splice variants) and 290 orthologues. Broad expression in testis (RPKM 32.8), endometrium (RPKM 14.4) and 24 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and Proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PSME4 Products(1)

mRNA	Protein	Name
NM_014614.3	NP_055429.2	proteasome activator complex subunit 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18845680	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSME4 Protein Structure

DUF3437

0
300
600
900
1200
1500
1843 a.a.

Protein Preferred Names

Protein Names

proteasome activator complex subunit 4

proteasome (prosome, macropain) activator subunit 4

PSME4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSME4	Q14997	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	PSME4	Q14997	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	PSME4	Q14997	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11334	PSME4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSME4	MGD	MGI:2143994
Felis catus	PSME4	VGNC	VGNC:81160
Macaca mulatta	PSME4	VGNC	VGNC:76295
Bos taurus	PSME4	VGNC	VGNC:33476
Rattus norvegicus	PSME4	RGD	RGD:1591971
Canis familiaris	PSME4	VGNC	VGNC:45119

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