Vgll4 - vestigial like family member 4 Gene

Mus musculus

Also known as VGL-4

Gene ID: 232334 | Gene type: protein coding

About Vgll4

Summary

Predicted to enable transcription coactivator binding activity. Involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and positive regulation of cellular protein catabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Vgll4 Products(6)

mRNA	Protein	Name
NM_001356371.2	NP_001343300.1	transcription cofactor vestigial-like protein 4 isoform 2
NM_001411599.1	NP_001398528.1	transcription cofactor vestigial-like protein 4 isoform 2
NM_001411600.1	NP_001398529.1	transcription cofactor vestigial-like protein 4 isoform 3 precursor
NM_001411601.1	NP_001398530.1	transcription cofactor vestigial-like protein 4 isoform 4
NM_001411602.1	NP_001398531.1	transcription cofactor vestigial-like protein 4 isoform 5
NM_177683.4	NP_808351.1	transcription cofactor vestigial-like protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15140898	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15140898	MGI
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	27720608	MGI
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	27720608	MGI
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	27720608	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15140898	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription cofactor vestigial-like protein 4

vestigial like 4

Vgll4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Vgll4	Q80V24	Tead4	Mus musculus	Q62296	GMS	24525233
Intra	Vgll4	Q80V24	Tead4	Mus musculus	Q62296	DLS	24525233
Intra	Vgll4	Q80V24	Tead4	Mus musculus	Q62296	X-Ray Diffraction	24525233

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137479	TEAD-IN-1	Inhibitor	/	Unkown
HY-RS15647	VGLL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vgll4	NCBI	NCBI:9686

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