2. Gene
  3. VGLL4 - vestigial like family member 4 Gene

VGLL4 - vestigial like family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VGL-4

Gene ID: 9686 | Gene type: protein coding

About VGLL4

Cytogenetic location: 3p25.3-p25.2 Genomic coordinates (GRCh38): 3:11,556,067-11,721,815 (from NCBI)

This gene has 18 transcripts (splice variants) and 267 orthologues. Ubiquitous expression in ovary (RPKM 26.1), thyroid (RPKM 18.5) and 25 other tissues.

Summary

Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VGLL4 Products(6)

mRNA Protein Name
NM_001128219.3 NP_001121691.1 transcription cofactor vestigial-like protein 4 isoform a
NM_001128220.3 NP_001121692.1 transcription cofactor vestigial-like protein 4 isoform c
NM_001128221.3 NP_001121693.1 transcription cofactor vestigial-like protein 4 isoform d
NM_001284390.2 NP_001271319.1 transcription cofactor vestigial-like protein 4 isoform e
NM_001284391.1 NP_001271320.1 transcription cofactor vestigial-like protein 4 isoform f
NM_014667.4 NP_055482.2 transcription cofactor vestigial-like protein 4 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
28051067 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
28051067 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
28051067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL4 Protein Structure

VGLL4

VGLL4: Transcription cofactor vestigial-like protein 4 (10 - 224)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 4

Vestigial-like 4

VGLL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Validated Y2H
32296183
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Anti Tag CoIP
33961781
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Y2H Prey Pooling
32296183
Intra
VGLL4 Q14135 TEAD3 Homo sapiens Q99594
Y2H Array
32296183
Intra
VGLL4 Q14135 TEAD4 Homo sapiens Q15561
BLI
24525233
Intra
VGLL4 Q14135 TEAD4 Homo sapiens Q15561
Anti Tag CoIP
33961781
Intra
VGLL4 Q14135 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
VGLL4 Q14135 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Validated Y2H
32296183
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Y2H Array
32296183
Intra
VGLL4 Q14135 TEAD2 Homo sapiens Q15562-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137479 TEAD-IN-1 Inhibitor / Unkown
HY-RS15647 VGLL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VGLL4 VGNC VGNC:36793
Canis familiaris VGLL4 VGNC VGNC:48260
Macaca mulatta VGLL4 VGNC VGNC:79755
Rattus norvegicus VGLL4 RGD RGD:1311653
Mus musculus VGLL4 MGD MGI:2652840
Felis catus VGLL4 VGNC VGNC:80753