PHLPP1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

Homo sapiens

Also known as SCOP; PHLPP; PPM3A; PLEKHE1

Gene ID: 23239 | Gene type: protein coding

About PHLPP1

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:62,715,541-62,980,433 (from NCBI)

This gene has 7 transcripts (splice variants), 246 orthologues and 31 paralogues. Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine Phosphatase family. The encoded protein promotes Apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of Cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated Insulin signaling. [provided by RefSeq, Dec 2011]

PHLPP1 Products(1)

mRNA	Protein	Name
NM_194449.4	NP_919431.2	PH domain leucine-rich repeat-containing protein phosphatase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18162466	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	28147277	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17386267	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	17386267	GOA
involved in regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	24530606	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	20513427	GOA
involved in regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	17386267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHLPP1 Protein Structure

LRR_1

LRR_8

LRR_1

LRR_8

PP2C

0
300
600
900
1200
1500
1717 a.a.

Protein Preferred Names

Protein Names

PH domain leucine-rich repeat-containing protein phosphatase 1

PH domain-containing family E member 1

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Uterine Corpus Endometrial Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19820A	NSC45586 sodium		≥98.0%	Unkown
HY-19820	NSC45586		/	Unkown
HY-RS10447	PHLPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHLPP1	VGNC	VGNC:44504
Bos taurus	PHLPP1	VGNC	VGNC:32840
Macaca mulatta	PHLPP1	VGNC	VGNC:81493
Rattus norvegicus	PHLPP1	RGD	RGD:621308
Felis catus	PHLPP1	VGNC	VGNC:107716
Mus musculus	PHLPP1	MGD	MGI:2138327

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