TASOR - transcription activation suppressor Gene

Homo sapiens

Also known as RAP140; TASOR1; se89-1; C3orf63; FAM208A

Gene ID: 23272 | Gene type: protein coding

About TASOR

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:56,620,132-56,683,265 (from NCBI)

This gene has 11 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 15.9), lymph node (RPKM 11.5) and 25 other tissues.

Summary

Enables chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; protein localization to heterochromatin; and regulation of gene expression. Located in heterochromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TASOR Products(7)

mRNA	Protein	Name
NM_001112736.2	NP_001106207.1	protein TASOR isoform a
NM_001363940.1	NP_001350869.1	protein TASOR isoform c
NM_001365635.2	NP_001352564.1	protein TASOR isoform d
NM_001365636.2	NP_001352565.1	protein TASOR isoform e
NM_001365637.2	NP_001352566.1	protein TASOR isoform f
NM_001365638.2	NP_001352567.1	protein TASOR isoform g
NM_015224.3	NP_056039.2	protein TASOR isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	29211708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26022416	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	26022416	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	29211708	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	28581500	GOA
involved in protein localization to heterochromatin	IDA IDA: Inferred from direct assay	28581500	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	28581500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TASOR Protein Structure

DUF3715

0
300
600
900
1200
1512 a.a.

Protein Preferred Names

Protein Names

protein TASOR

CTCL tumor antigen se89-1

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 75

RP75	Retinitis Pigmentosa, Type 75

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14222	TASOR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14223	TASOR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TASOR	VGNC	VGNC:28783
Felis catus	TASOR	VGNC	VGNC:65962
Mus musculus	TASOR	MGD	MGI:1921694
Canis familiaris	TASOR	VGNC	VGNC:40652
Rattus norvegicus	TASOR	RGD	RGD:1595469
Macaca mulatta	TASOR	VGNC	VGNC:78243

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