2. Gene
  3. MPHOSPH8 - M-phase phosphoprotein 8 Gene

MPHOSPH8 - M-phase phosphoprotein 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TWA3; mpp8; HSMPP8

Gene ID: 54737 | Gene type: protein coding

About MPHOSPH8

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,633,659-19,673,441 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 20.0), spleen (RPKM 15.8) and 25 other tissues.

Summary

Enables chromatin binding activity and methylated histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; regulation of DNA methylation; and regulation of gene expression. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

MPHOSPH8 Products(1)

mRNA Protein Name
NM_017520.4 NP_059990.2 M-phase phosphoprotein 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
29211708 GOA
enables histone reader activity IDA
IDA: Inferred from direct assay
20871592 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
20871592 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20871592 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
20871592 GOA
involved in negative regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
26022416 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: Inferred from mutant phenotype
29211708 GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation IDA
IDA: Inferred from direct assay
28581500 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8885239 GOA
located in heterochromatin IDA
IDA: Inferred from direct assay
20871592 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
20871592 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8885239 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPHOSPH8 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (59 - 109)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (573 - 663)

Ank

Ank: Ankyrin repeat (666 - 696)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 860 a.a.
Protein Preferred Names Protein Names

M-phase phosphoprotein 8

M-phase phosphoprotein, mpp

MPHOSPH8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MPHOSPH8 Q99549 EHMT1 Homo sapiens Q9H9B1
Anti Tag CoIP
26496610
Intra
MPHOSPH8 Q99549 EHMT1 Homo sapiens Q9H9B1
Anti Bait CoIP
20871592
Intra
MPHOSPH8 Q99549 SETDB1 Homo sapiens Q15047
Anti Bait CoIP
20871592
Intra
MPHOSPH8 Q99549 H3C1 Homo sapiens P68431
Protein Array
20871592
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08612 MPHOSPH8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MPHOSPH8 VGNC VGNC:31575
Mus musculus MPHOSPH8 MGD MGI:1922589
Rattus norvegicus MPHOSPH8 RGD RGD:1305133
Macaca mulatta MPHOSPH8 VGNC VGNC:74864
Felis catus MPHOSPH8 VGNC VGNC:63571