SIN3B - SIN3 transcription regulator family member B Gene

Homo sapiens

Gene ID: 23309 | Gene type: protein coding

About SIN3B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,829,398-16,880,349 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SIN3B Products(3)

mRNA	Protein	Name
NM_001297595.2	NP_001284524.1	paired amphipathic helix protein Sin3b isoform 2
NM_001297597.2	NP_001284526.1	paired amphipathic helix protein Sin3b isoform 3
NM_015260.4	NP_056075.1	paired amphipathic helix protein Sin3b isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12670868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIN3B Protein Structure

PAH

Sin3_corepress

0
200
400
600
800
1000
1162 a.a.

Protein Preferred Names

Protein Names

paired amphipathic helix protein Sin3b

SIN3 homolog B, transcriptional regulator

Related Diseases

Diseases

Alias

Witteveen-Kolk Syndrome

WITKOS	Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation
Sin3a-Related Intellectual Disability Syndrome

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12926	SIN3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIN3B	MGD	MGI:107158
Bos taurus	SIN3B	VGNC	VGNC:34625
Macaca mulatta	SIN3B	VGNC	VGNC:77276
Rattus norvegicus	SIN3B	RGD	RGD:1587989
Canis familiaris	SIN3B	VGNC	VGNC:46178
Felis catus	SIN3B	VGNC	VGNC:65151

Name
Email *

	Sorry, but the email address you supplied was invalid.