NCAPD3 - non-SMC condensin II complex subunit D3 Gene

Homo sapiens

Also known as CAPD3; hcp-6; CAP-D3; MCPH22; hHCP-6; hCAP-D3

Gene ID: 23310 | Gene type: protein coding

About NCAPD3

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,150,113-134,225,461 (from NCBI)

This gene has 29 transcripts (splice variants), 193 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in prostate (RPKM 42.0), bone marrow (RPKM 7.1) and 20 other tissues.

Summary

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]

NCAPD3 Products(5)

mRNA	Protein	Name
NM_001372065.1	NP_001358994.1	condensin-2 complex subunit D3 isoform 3
NM_001372068.1	NP_001358997.1	condensin-2 complex subunit D3 isoform 2
NM_001372069.1	NP_001358998.1	condensin-2 complex subunit D3 isoform 4
NM_001372070.1	NP_001358999.1	condensin-2 complex subunit D3 isoform 4
NM_015261.3	NP_056076.1	condensin-2 complex subunit D3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	20622854	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17268547	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	14532007	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	27737959	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of condensin complex	IDA IDA: Inferred from direct assay	14532007	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	20551165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAPD3 Protein Structure

Cohesin_HEAT

Cnd1

0
300
600
900
1200
1498 a.a.

Protein Preferred Names

Protein Names

condensin-2 complex subunit D3

NCAPD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCAPD3	P42695	NCAPH2	Homo sapiens	Q6IBW4	Anti Tag CoIP	26496610
Intra	NCAPD3	P42695	NCAPH2	Homo sapiens	Q6IBW4	Anti Bait CoIP	17268547
Intra	NCAPD3	P42695	GAPDH	Homo sapiens	P04406	Anti Bait CoIP	29028794
Intra	NCAPD3	P42695	EPRS1	Homo sapiens	P07814	Anti Bait CoIP	29028794

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly 22, Primary, Autosomal Recessive

MCPH22

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly 19, Primary, Autosomal Recessive

MCPH19	Primary Autosomal Recessive Microcephaly 19
Microcephaly, Type 19, Primary, Autosomal Recessive

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09067	NCAPD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NCAPD3	MGD	MGI:2142989
Macaca mulatta	NCAPD3	VGNC	VGNC:75037
Felis catus	NCAPD3	VGNC	VGNC:63731
Bos taurus	NCAPD3	VGNC	VGNC:31902
Rattus norvegicus	NCAPD3	RGD	RGD:1562176
Canis familiaris	NCAPD3	VGNC	VGNC:43640

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