DOCK9 - dedicator of cytokinesis 9 Gene

Homo sapiens

Also known as ZIZ1; ZIZIMIN1

Gene ID: 23348 | Gene type: protein coding

About DOCK9

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:98,793,429-99,088,619 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 21.7), thyroid (RPKM 20.1) and 23 other tissues.

Summary

Enables cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

DOCK9 Products(14)

mRNA	Protein	Name
NM_001130048.2	NP_001123520.1	dedicator of cytokinesis protein 9 isoform b
NM_001130049.2	NP_001123521.1	dedicator of cytokinesis protein 9 isoform c
NM_001130050.2	NP_001123522.1	dedicator of cytokinesis protein 9 isoform d
NM_001318849.2	NP_001305778.1	dedicator of cytokinesis protein 9 isoform e
NM_001366676.2	NP_001353605.1	dedicator of cytokinesis protein 9 isoform 6
NM_001366677.2	NP_001353606.1	dedicator of cytokinesis protein 9 isoform 7
NM_001366678.2	NP_001353607.1	dedicator of cytokinesis protein 9 isoform 8
NM_001366679.2	NP_001353608.1	dedicator of cytokinesis protein 9 isoform 9
NM_001366680.2	NP_001353609.1	dedicator of cytokinesis protein 9 isoform 10
NM_001366681.2	NP_001353610.1	dedicator of cytokinesis protein 9 isoform 11
NM_001366682.2	NP_001353611.1	dedicator of cytokinesis protein 9 isoform 12
NM_001366683.2	NP_001353612.1	dedicator of cytokinesis protein 9 isoform 13
NM_001366684.2	NP_001353613.1	dedicator of cytokinesis protein 9 isoform 14
NM_015296.3	NP_056111.1	dedicator of cytokinesis protein 9 isoform a

DOCK9 Protein Structure

DUF3398

DOCK-C2

DHR-2

0
400
800
1200
1600
2068 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 9

cdc42 guanine nucleotide exchange factor zizimin-1

Related Diseases

Diseases

Alias

Irregular Astigmatism

Corneal Ectasia

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

Brittle Cornea Syndrome 1

Brittle Cornea Syndrome	Fragilitas Oculi With Joint Hyperextensibility
Dysgenesis Mesodermalis Corneae Et Sclerae	BCS1
Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility	Ehlers-Danlos Syndrome, Type Vib, Formerly
Eds6b, Formerly	Type Vib Ehlers-Danlos Syndrome
Eds Vib	Ehlers-Danlos Syndrome Type 6b
Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility	Eds6b Formerly
Ehlers-Danlos Syndrome Type Vib Formerly	Ehlers-Danlos Syndrome Type 6
Cornea, Brittle, Syndrome	Cornea, Brittle, Syndrome, Type 1
Ehlers-Danlos Syndrome 6b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-RS03931	DOCK9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DOCK9	VGNC	VGNC:61578
Rattus norvegicus	DOCK9	RGD	RGD:629617
Canis familiaris	DOCK9	VGNC	VGNC:40053
Bos taurus	DOCK9	VGNC	VGNC:28163
Mus musculus	DOCK9	MGD	MGI:106321
Macaca mulatta	DOCK9	VGNC	VGNC:71835

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