CRTC1 - CREB regulated transcription coactivator 1 Gene

Homo sapiens

Also known as MAML2; MECT1; Mam-2; TORC1; TORC-1; WAMTP1

Gene ID: 23373 | Gene type: protein coding

About CRTC1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,683,680-18,782,333 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in brain (RPKM 4.7), testis (RPKM 2.0) and 24 other tissues.

Summary

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CRTC1 Products(2)

mRNA	Protein	Name
NM_001098482.2	NP_001091952.1	CREB-regulated transcription coactivator 1 isoform 3
NM_015321.3	NP_056136.2	CREB-regulated transcription coactivator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	14536081	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14506290	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14536081	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14506290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTC1 Protein Structure

TORC_N

TORC_M

TORC_C

0
100
200
300
400
500
634 a.a.

Protein Preferred Names

Protein Names

CREB-regulated transcription coactivator 1

Mastermind-like protein 2

Related Diseases

Diseases

Alias

Mucoepidermoid Carcinoma

Mec	Salivary Gland Mucoepidermoid Carcinoma
C3772	Carcinoma Mucoepidermoid
Carcinoma, Mucoepidermoid

Salivary Gland Carcinoma

Salivary Gland Cancer	Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms

Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1

Lacrimal Gland Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Lacrimal Gland

Cutaneous Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Skin

Mucoepidermoid Skin Carcinoma

Bronchus Mucoepidermoid Carcinoma

Clear Cell Hidradenoma

Clear Cell Myoepithelioma

Eccrine Acrospiroma

Breast Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Breast

Mucoepidermoid Carcinoma Of The Breast

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma

Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri

Lipoadenoma

Hidradenoma

Adenoma, Sweat Gland	Hidradenoma Of Skin
Sweat Gland Adenoma	Syringoadenoma
Eccrine Acrospiroma	Benign Neoplasm Of Sweat Gland

Necrotizing Sialometaplasia

Sialometaplasia, Necrotizing

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma	Adenomyo-Epithelioma
Clear Cell Carcinoma	Emc
Epithelial Myoepithelial Carcinoma	Glycogen-Rich Adenocarcinoma
Glycogen-Rich Adenoma	Monomorphic Clear Cell Tumor
Tubular Solid Adenoma	Adenocarcinoma, Clear Cell

Mammary Analogue Secretory Carcinoma

Endobronchial Lipoma

Tonsil Cancer

Tonsillar Neoplasms	Malignant Neoplasm Of Faucial Tonsil
Malignant Neoplasm Of Palatine Tonsil	Malignant Neoplasm Of Tonsil, Faucial
Malignant Tonsillar Tumor	Malignant Tumor Of Tonsil
Tonsillar Carcinoma	Malignant Neoplasm Tonsil

Schneiderian Carcinoma

Cylindrical Cell Carcinoma

Bile Duct Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Bile Duct

Extrahepatic Bile Duct Mucoepidermoid Carcinoma

Breast Metaplastic Carcinoma

Metaplastic Carcinoma Of The Breast	Metaplastic Breast Carcinoma
Metaplastic Carcinoma Of Breast	Metaplastic Breast Cancer

Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland	Sweat Gland Tumor
Tumor Of The Sweat Gland	Sweat Gland Neoplasms
Sweat Gland Neoplasm

Esophageal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma, Esophagus

Eccrine Acrospiroma

Acrospiroma	Poroma
Eccrine Hidradenoma	Eccrine Hidradenoma Of Skin
Hidradenoma	Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland	Eccrine Poroma

Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma

Oropharynx Cancer

Oropharyngeal Cancer	Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx	Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx	Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult	Cancer Of The Oropharynx

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm	Eccrine Tumor
Eccrine Neoplasm	Malignant Eccrine Neoplasm

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma

Acinar Cell Carcinoma

Acinic Cell Carcinoma	Acinic Cell Tumor
Carcinoma Acinar Cell	Carcinoma, Acinar Cell
Acinar Cell Tumor

Lacrimal System Cancer

Neoplasm Of Lacrimal System	Lacrimal System Neoplasm
Tumor Of The Lacrimal System

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Sweat Gland Disease

Sweat Gland Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03200	CRTC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRTC1	VGNC	VGNC:103667
Rattus norvegicus	CRTC1	RGD	RGD:1589158
Macaca mulatta	CRTC1	VGNC	VGNC:71418
Mus musculus	CRTC1	MGD	MGI:2142523
Felis catus	CRTC1	VGNC	VGNC:61192
Bos taurus	CRTC1	VGNC	VGNC:27728